Sökning: "Monika Vestling"

Hittade 1 avhandling innehållade orden Monika Vestling.

1. 1. Alzheimer's disease mutations and cellular signalling

   Författare :Monika Vestling; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alzheimer's disease is the most frequent cause of dementia in elderly and is characterised neuropathologically by the extracellular deposition of amyloid plaques (containing the 39-43 amino acid Abeta peptide), as well as intracellular neurofibrillary tangles (NFTs) composed primarily of an abnormally hyperphosphorylated form of the microtubule-associated protein tau. A proportion (10- 15%) of Alzheimer's disease cases is familial, the remainder being sporadic. LÄS MER