Sökning: "Molekylär medicin"

Visar resultat 16 - 20 av 637 avhandlingar innehållade orden Molekylär medicin.

  1. 16. Defining the importance of protein geranylgeranylation in innate immunity

    Författare :Murali K Akula; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAAX proteins; GGTase-I; RAC1; statins;

    Sammanfattning : RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed to target proteins to membranes where they encounter effector molecules that stimulate GTP-binding and activation. LÄS MER

  3. 17. Protein kinase STK25 is a regulator of hepatic lipid partitioning and whole body metabolism

    Författare :Manoj Amrutkar; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NAFLD; NASH; Liver lipid metabolism; Type 2 diabetes; STK25;

    Sammanfattning : In past decade, type 2 diabetes (T2D) and associated metabolic complications have become a major global threat for human health with epidemic increase in incidence. Currently available treatments for T2D have several limitations and side effects making it difficult safely reach adequate metabolic control. LÄS MER

  4. 18. Factors influencing prognosis in acute coronary syndrome - A report from the SWEDEHEART registry

    Författare :Oskar Angerås; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute coronary syndrome; acute myocardial infarction; risk factors; obesity paradox; socioeconomic status; cardiogenic shock; thrombus aspiration; SWEDEHEART; SCAAR; RIKS-HIA;

    Sammanfattning : Background: Acute coronary syndrome (ACS) is one of the major causes of mortality in the world. The prognosis for patients with ACS is affected by several factors, such as baseline characteristics and treatment before, during and after hospitalisation. . LÄS MER

  5. 19. Clinical relevance of high-sensitive Troponin T in cardiovascular disease

    Författare :Christian Bjurman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; prognostic score; mortality; heart failure; myocardial infarction; renal dysfunction;

    Sammanfattning : Background and aims: Troponin T (hs-cTnT) is a cardiac damage marker used in the diagnosis of non-ST segment elevation myocardial infarction (NSTEMI) and for prognostic assessment. Clinical decision-making should ideally be based on evidence. LÄS MER

  7. 20. Susceptibility to chronic liver disease

    Författare :Maria Antonella Burza; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic liver disease; susceptibility; human genetics; NAFLD; ALD; PNPLA3;

    Sammanfattning : The onset and the progression of chronic liver disease involve environmental and genetic factors. Hepatic stellate cells (HSCs) are important players in these processes and are the main storage site for retinol. LÄS MER