Sökning: "Molekylär cellbiologi"

Visar resultat 16 - 20 av 158 avhandlingar innehållade orden Molekylär cellbiologi.

  1. 16. Role of lactobacilli in Helicobacter pylori pathogenesis and host cell responses

    Författare :Hanna Gebreegziabher Gebremariam; Ann-Beth Jonsson; Keira Melican; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Helicobacter pylori; Inflammation; Lactobacillus; ADAM17; Proinflammatory cytokines; Lactate; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Helicobacter pylori is well adapted to the harsh environment of the human stomach, allowing it to persistently colonize the gastric mucosa of at least 50% of the global population for decades. Long-term colonization induces chronic inflammation that can eventually lead to development of peptic ulcer and gastric cancer. LÄS MER

  3. 17. RNA Polymerase I regulation by chromatin remodelling

    Författare :Yuan Guo; Ann-Kristin Östlund Farrants; Marikki Laiho; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA Pol I; ribosome genes; chromatin remodelling; WSTF; CHD4; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Cell proliferation and growth is correlated with effective protein synthesis and ribosome biogenesis. The transcription of the 47S pre-ribosomal RNA by RNA Polymerase I (RNA Pol I) machinery is the rate-limiting step of ribosome biogenesis and can accounts for more than 50% of total cellular transcription. LÄS MER

  4. 18. Regulation of cellular Hsp70 : Proteostasis and aggregate management

    Författare :Jayasankar Mohanakrishnan Kaimal; Claes Andréasson; Pierre Goloubinoff; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Proteins have to be folded to their native structures to be functionally expressed. Misfolded proteins are proteotoxic and negatively impact on cellular fitness. To maintain the proteome functional proteins are under the constant surveillance of dedicated molecular chaperones that perform protein quality control (PQC). LÄS MER

  5. 19. The diverse functions of the ADAR enzymes : Editing and editing-independent effects on gene expression

    Författare :Victor Karlström; Neus Visa; Ayelet Lamm; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editing; ADAR; Alternative splicing; miRNA processing; neuronal differentiaton; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The adenosine deaminase acting on RNA (ADAR) family of enzymes consists of three members (ADAR1-3). These enzymes are responsible for the deamination of adenosine into inosine in double-stranded RNA, one of the most common RNA modifications in mammals. LÄS MER

  7. 20. Controlling protein homeostasis through regulation of Heat shock factor 1

    Författare :Anna E. Masser; Claes Andréasson; Marie Öhman; David Pincus; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stress; protein homeostasis; molecular chaperones; heat shock response; Hsf1; Hsp70; Saccharomyces cerevisiae; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : In order to thrive in a changing environment all organisms need to ensure protein homeostasis (proteostasis). Proteostasis is ensured by the proteostasis system that monitors the folding status of the proteome and regulates cell physiology and gene expression to counteract any perturbations. LÄS MER