Sökning: "Molekylär Endokrinologi"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden Molekylär Endokrinologi.

  1. 1. Insulin Resistance : Causes, biomarkers and consequences

    Författare :Christoph Nowak; Tove Fall; Erik Ingelsson; Johan Sundström; Rachel Freathy; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin resistance; diabetes; insulin secretion; cardiovascular; mendelian randomization; proteomics; metabolomics; genomics; molecular epidemiology; complex disease; risk prediction; coronary heart disease; stroke; hyperglycemia;

    Sammanfattning : The worldwide increasing number of persons affected by largely preventable diseases like diabetes demands better prevention and treatment. Insulin is required for effective utilisation of circulating nutrients. LÄS MER

  3. 2. Exploring food concepts for the prevention of type 2 diabetes

    Författare :Ulrika Axling; Molekylär endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glycaemic index; whole grain; Type 2 diabetes; obesity; rose hip;

    Sammanfattning : There is currently a dramatic and global increase in obesity, type 2 diabetes (T2D) and associated metabolic disorders. T2D can be delayed or prevented in individuals at risk and identifying and developing new food concepts for the prevention of obesity and T2D is of utmost importance. LÄS MER

  4. 3. Hormone-Sensitive Lipase - New roles in adipose tissue biology

    Författare :Kristoffer Ström; Molekylär endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinoid; adipogenesis; adipocyte determination; HSL; WAT;

    Sammanfattning : Obesity is defined as abnormal or excessive fat accumulation that may impair health, and increased knowledge about the enzymes controlling lipid metabolism is of great importance in order to combat this disease. Hormone-sensitive lipase (HSL) is a key enzyme in the mobilization of fatty acids from acylglycerols in adipocytes, but also plays important roles in other cell types. LÄS MER

  5. 4. Tissue Microarrays for Analysis of Expression Patterns

    Författare :Cecilia Lindskog Bergström; Fredrik Pontén; Anna Asplund; Ari Ristimäki; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue microarrays; Antibody-based proteomics; Immunohistochemistry; Biomarker discovery; Diabetes; Lung cancer; Influenza virus; Evolution; Pathology; Patologi;

    Sammanfattning : Proteins are essential building blocks in every living cell, and since the complete human genome was sequenced in 2004, researchers have attempted to map the human proteome, which is the functional representation of the genome. One such initiative is the Human Protein Atlas programme (HPA), which generates monospecific antibodies towards all human proteins and uses these for high-throughput tissue profiling on tissue microarrays (TMAs). LÄS MER

  7. 5. New Insights in Adrenal Tumourigenesis

    Författare :Rajani Maharjan; Peyman Björklund; Michaela Luconi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cortisol producing adenomas; adrenocortical carcinomas; mutation; heterogeneity; PRKACA; TERT; CTNNB1; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Unilateral cortisol producing adenoma (CPA) is the most common cause of ACTH-independent Cushing’s syndrome and is surgically curable. On the other hand, adrenocortical carcinomas (ACCs) are rare and aggressive tumours. LÄS MER