Sökning: "Molecular biophysics"

Visar resultat 11 - 15 av 191 avhandlingar innehållade orden Molecular biophysics.

  1. 11. Protein Folding and DNA Origami

    Författare :Mark Marvin Seibert; David van der Spoel; Helmut Grubmüller; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; Molecular Dynamics simulations; DNA origami; Biophysics; Biofysik; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Sammanfattning : In this thesis, the folding process of the de novo designed polypeptide chignolin was elucidated through atomic-scale Molecular Dynamics (MD) computer simulations. In a series of long timescale and replica exchange MD simulations, chignolin’s folding and unfolding was observed numerous times and the native state was identified from the computed Gibbs free-energy landscape. LÄS MER

  3. 12. KNOW YOUR ENEMY : Characterizing Pathogenic Biomaterials Using Laser Tweezers

    Författare :Tobias Dahlberg; Magnus Andersson; Krister Wiklund; Mikael Sjödahl; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Optical Tweezers; Laser Tweezers; Raman Spectroscopy; Bacterial Adhesion; Biophysics; Pili; Bacterial Spores; Endospores; Oocysts; Cryptosporidium; Optics; biology; biologi; fysik; Physics;

    Sammanfattning : Diseases caused by pathogenic agents such as bacteria and viruses result in devastating costs on personal and societal levels. However, it is not just the emergence of new diseases that is problematic. Antibiotic resistance among bacteria makes uncomplicated infections difficult and lethal. LÄS MER

  4. 13. Unveiling Mechanistic Details of Macromolecular Interactions: Structural Design and Molecular Modelling of DNA-Protein Systems in Their Active State

    Författare :Anna Reymer; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molecular modelling; intercalation; homologous recombination; DNA; ruthenium II polypyridyl compounds; human Rad51;

    Sammanfattning : Molecular structure is fundamental for understanding mechanisms of molecular interactions. This applies not least to understanding biological function: every biological cell, whether bacterial or human, is an immensely complex system of thousands of molecules that exist in constant motion and interaction with each other. LÄS MER

  5. 14. Crystallography in Four Dimensions : Methods and Applications

    Författare :Gunilla Carlsson; Janos Hajdu; Dieter Oesterhelt; Vilmos Fülöp; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; horseradish peroxidase; redox reactions; X-ray crystallography; haem catalysis; molecular movies; radiation damage; Molekylär biofysik; Molecular biophysics; Molekylär biofysik;

    Sammanfattning : The four-electron reduction of dioxygen to water is the most exothermic non-photochemical reaction available to biology. A detailed molecular description of this reaction is needed to understand oxygen-based redox processes. Horseradish peroxidase (HRP) is a haem-containing redox enzyme capable of catalysing the reduction of dioxygen to water. LÄS MER

  7. 15. Simulating Functional Cycles and Drug Modulation in Ligand-gated Ion Channels

    Författare :Yuxuan Zhuang; Erik Lindahl; Grace Brannigan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channels; molecular dynamics; markov state model; lipid modulation; nicotinic receptor; protein conformational transitions; Biophysics; biofysik;

    Sammanfattning : Understanding the intricate motions and conformational changes that govern biological processes remains a fascinating and challenging endeavor. The research presented in this thesis aims to elucidate the dynamic processes underlying biological functions, specifically focusing on the dynamics of pentameric ligand-gated ion channels (pLGICs), which play a crucial role in signal transduction within the brain. LÄS MER