Sökning: "Molecular Modelling"
Visar resultat 6 - 10 av 289 avhandlingar innehållade orden Molecular Modelling.
6. Molecular modelling - understanding and prediction of enzyme selectivity
Sammanfattning : Molecular modelling strategies for evaluation of enzyme selectivity wereinvestigated with a focus on principles of how molecular interactionscould be evaluated to provide information about selectivity. Althoughmolecular modelling provides tools for evaluation of geometrical andenergy features of molecular systems, no general strategies for evaluationof enzyme selectivity exist. LÄS MER
7. Unveiling Mechanistic Details of Macromolecular Interactions: Structural Design and Molecular Modelling of DNA-Protein Systems in Their Active State
Sammanfattning : Molecular structure is fundamental for understanding mechanisms of molecular interactions. This applies not least to understanding biological function: every biological cell, whether bacterial or human, is an immensely complex system of thousands of molecules that exist in constant motion and interaction with each other. LÄS MER
8. Cyclic Sulfamide HIV-1 Protease Inhibitors : Design, Synthesis and Modelling
Sammanfattning : Ten years ago, the first protease inhibitor targeting the human immunodeficiency virus (HIV) was approved for clinical use. Highly active antiretroviral therapy (HAART), which combined protease and reverse transcriptase inhibitors, quickly became the standard therapy for treating patients infected with HIV and Acquired Immune Deficiency Syndrome (AIDS). LÄS MER
9. Unravelling Mechanistic Insights of Eukaryotic Transcriptional Control
Sammanfattning : DNA transcription involves the association of multiple proteins with DNA to convert the genetic information into messenger-RNA transcripts, which later will be translated into proteins. Con-trolled regulation of transcription is imperative for preserving the healthy and homeostatic state of cells. LÄS MER
10. Nonlinear materials for optical power limiting : characterization and modelling
Sammanfattning : High power laser pulses can be a threat to optical sensors, including the human eye. Traditionally this threat has been alleviated by colour filters that block radiation in chosen wavelength ranges. LÄS MER