Sökning: "Molecular Cellbiology"

Visar resultat 6 - 10 av 48 avhandlingar innehållade orden Molecular Cellbiology.

1. 6. Molecular And Cellular Networks in Critical Illness Associated Muscle Weakness : Skeletal Muscle Proteostasis in the Intensive Care Unit

   Författare :Varuna Chaminda Banduseela; Lars Larsson; Gustavo Nader; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chaperones; autophagy; intensive care unit; heat shock proteins; protein synthesis; proteostasis; ER stress; gene expression; sepsis; neuromuscular blockers; corticosteroids; immobilisation; mechanical ventilation; Molekylär cellbiologi; Molecular Cellbiology; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Critical illness associated muscle weakness and muscle dysfunction in intensive care unit (ICU) patients lead to severe morbidity and mortality as well as significant adverse effect on quality of life. Immobilization, mechanical ventilation, neuromuscular blocking agents, corticosteroids, and sepsis have been implicated as important risk factors, but the underlying molecular and cellular mechanisms remain unclear. LÄS MER

3. 7. Nuclear pore membrane glycoprotein 210 as a new marker for epithelial cells

   Författare :Magnus Olsson; Neus Visa; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Nuclear pore complex; gp210; Nulp1; epithelial cells; kidney development; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Epithelial cell polarisation is a prerequisite for the branching morphogenesis in several organs. Differential screening techniques were used to identify genes, which are upregulated during induction of epithelium in early kidney development. LÄS MER

4. 8. Specific signaling through heteromeric PDGF receptor complexes

   Författare :Simon Ekman; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal cells and exert its effect by binding to two structurally related receptor tyrosine kinases, denoted α- and β-receptors. PDGF binding induces dimerization of its receptors, both homo-and heterodimerization, leading to their autophosphorylation on tyrosine residues and binding of downstream signaling molecules. LÄS MER

5. 9. Mechanisms for TGF-β-Mediated Regulation of the Actin Filament System and Apoptosis

   Författare :Sofia Edlund; Pontus Aspenström; Maréne Landström; Tommy Andersson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-beta; cytoskeleton; GTPases; mitogen-activated protein kinase kinase 3; TGF-beta-activated kinase 1; Apoptosis; Smad7; beta-catenin; p38 MAPK; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Transforming growth factor-β (TGF-β) is a member of a large superfamily of cytokines which participate in many different types of cellular processes, such as growth inhibition, cell migration, differentiation, cell adhesion, wound healing and immunosuppression. Alterations of TGF-β superfamily signalling results in several different disorders, including bone disease, vascular disease and cancer. LÄS MER

7. 10. Laminin-1 and receptors : Laminin α1 chain in important for epithelial development

   Författare :Mats Falk; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; basement membrane; gene targeting; laminin α1; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Laminins are heterotrimeric glycoproteins that are major components of all basement membranes. Integrins from the β1 -famjly and the dystroglycan complex have been shown to be important receptors attaching epithelial cells to the underlying basement membrane. LÄS MER