Sökning: "Molecular Cellbiology"

Visar resultat 16 - 20 av 48 avhandlingar innehållade orden Molecular Cellbiology.

1. 16. Cellular Interactions with Extracellular Matrix During Development and in Muscle Disease

   Författare :Carl-Fredrik Tiger; Anders Aspberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; integrin; laminin; collagen; muscle; tendon; skeleton; mouse; human; development; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : The formation and maintenance of tissues in multicellular animals are crucially dependent on cellular interactions with the extracellular matrix (ECM). Two different studies on such interactions are presented herein. LÄS MER

3. 17. Muscle cell integrins in vitro and in vivo : Identification and characterisation of a novel integrin, α11β1

   Författare :Teet Velling; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; integrins; α7 integrin; α11 integrin; embryonic development; muscle; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Integrins are heterodimeric receptors composed of non-covalently associated αand β subunits which have distinct functions on different cell types. α7β1integrin is an important laminin receptor in skeletal muscle. The mRNA andprotein expression patterns of α7A and α7B splice variants during mousedevelopment were studied. LÄS MER

4. 18. Tumor-stroma interactions in hepatocellular carcinoma

   Författare :Nataša Pavlović; Femke Heindryckx; Jessica Maiers; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatocellular carcinoma; fibrosis; endoplasmic reticulum stress; unfolded protein response; platelets; P2Y12; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : Hepatocellular carcinoma (HCC), a highly deadly primary liver cancer with a rising global incidence and limited therapeutic options, is characterized by a vicious cross-talk between the tumor and its surrounding hepatic stroma. The stromal environment, consisting of hepatic stellate cells (HSC), endothelial cells, resident and infiltrating macrophages and other immune cells, platelets and extracellular matrix (ECM) components, actively contributes to creating an ideal niche for tumor proliferation and invasiveness. LÄS MER

5. 19. Adhesion Dependent Signals : Cell Survival, Receptor Crosstalk and Mechanostimulation

   Författare :Anjum Riaz; Staffan Johansson; Bengt Hallberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Integrins; Signal transduction; Protein kinase B; Akt; PI3K; Heparanase; ROS; Mechanosignalling; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Cellforskning; Cell Research;

   Sammanfattning : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. LÄS MER

7. 20. The role of RNA in prion aggregation and disease

   Författare :Petar Stefanov Kovachev; Suparna Sanyal; Per Jemth; Magnus Wolf-Watz; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : As humanity evolved to witness an exceptionally high standard of living, Alzheimer’s, cancer and diabetes gradually replaced infections as the main limiting factors in longevity. It is both disturbing and captivating that such degenerative conditions are caused by the most ubiquitous biomolecule – the protein. LÄS MER