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Visar resultat 1 - 5 av 109 avhandlingar som matchar ovanstående sökkriterier.
1. The effects of glucocorticoids on brown fat : physiological and molecular studies
Sammanfattning : Brown adipose tissue (BAT) is the main site for non-shivering thermogenesis in most mammals. The BAT-specific uncoupling protein-1 (UCP1) uncouples substrate oxidation from ATP production and hereby decreases metabolic efficiency. LÄS MER
2. Metal homeostasis as critical determinant for cellular fitness
Sammanfattning : Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and manganese regulate a plethora of cellular processes ranging from signaling and oxidative stress to proteostasis and energy metabolism. LÄS MER
3. Controlling protein homeostasis through regulation of Heat shock factor 1
Sammanfattning : In order to thrive in a changing environment all organisms need to ensure protein homeostasis (proteostasis). Proteostasis is ensured by the proteostasis system that monitors the folding status of the proteome and regulates cell physiology and gene expression to counteract any perturbations. LÄS MER
4. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting
Sammanfattning : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. LÄS MER
5. On the Design of Affibody Molecules for Radiolabeling and In Vivo Molecular Imaging
Sammanfattning : Affibody molecules have lately shown great potential as tools for in vivo molecular imaging. These small, 3-helical bundles, with their highly stable protein scaffold, are well suited for the often harsh conditions of radiolabeling. LÄS MER