Sökning: "Mohamed Mahmoud Issa"

Hittade 1 avhandling innehållade orden Mohamed Mahmoud Issa.

1. 1. Linear and Branched Chitosan Oligomers as Delivery Systems for pDNA and siRNA In Vitro and In Vivo

   Författare :Mohamed Mahmoud Issa; Per Artursson; Arto Urtti; Uppsala universitet; []
   Nyckelord :Medical sciences; Chitosan oligomers; gene delivery; gene expression; pDNA; siRNA; MEDICIN OCH VÅRD;

   Sammanfattning : In this thesis, chitosan, a biocompatible polysaccharide that has been approved as a food additive was selected as a platform for the development of safe, efficient non-viral gene delivery systems to mammalian cells. Previously, chitosan-based gene formulations had been generally associated with high molecular weight chitosans, which were poorly characterised in terms of molecular weight distribution and degree of acetylation. LÄS MER