Sökning: "Modulated activity"

Visar resultat 1 - 5 av 160 avhandlingar innehållade orden Modulated activity.

  1. 1. Autonomic nervous system regulation in chronic neck-shoulder pain : Relations to physical activity and perceived stress

    Författare :David Hallman; Eugene Lyskov; Bengt Arnetz; Ewa Wigaeus Tornqvist; Allan Toomingas; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autonomic imbalance; Daily physical activity; Trapezius myalgia; Treatment; Parasympathetic; Sympathetic;

    Sammanfattning : Neck-shoulder pain (NSP) is a highly prevalent musculoskeletal disorder with unclear causes, and effective prevention and treatment require a further understanding of the underlying mechanisms. Aberrant autonomic nervous system (ANS) regulation is a hypothesized causal element in the development and maintenance of chronic muscle pain. LÄS MER

  3. 2. Role of Multiple Glutathione Transferases in Bioactivation of Thiopurine Prodrugs : Studies of Human Soluble Glutathione Transferases from Alpha, Kappa, Mu, Omega, Pi, Theta, and Zeta Classes

    Författare :Birgitta I. Eklund; Bengt Mannervik; Mikael Widersten; Ralf Morgenstern; Uppsala universitet; []
    Nyckelord :Biochemistry; Glutathione Transferases; Thiopurines; Prodrug; Bioactivation; Screening Method; Chemotherapy; Functional plasticity; Modulated activity; Biokemi;

    Sammanfattning : A screening method was developed for identification of catalytically active enzymes in combinatorial cDNA libraries of mutated glutathione transferase (GST) derivatives expressed in E. coli. The method is based on spraying monochlorobimane (MCB) directly over bacterial colonies growing on agar. LÄS MER

  4. 3. Endogenous and exogenous factors affecting lipoprotein lipase activity

    Författare :Mikael Larsson; Gunilla Olivecrona; Aivar Lookene; Ira Tabas; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LPL; APOC1; APOC2; APOC3; ANGPTL4; enzyme inactivation; lipoprotein metabolism; triglycerides; fatty acids; hypertriglyceridemia; CVD; small molecule screening; structure-activity relationship; cardiovascular disease; hjärt- och kärlforskning;

    Sammanfattning : Individuals with high levels of plasma triglycerides are at high risk to develop cardiovascular disease (CVD), currently one of the major causes of death worldwide. Recent epidemiological studies show that loss-of-function mutations in the APOC3 gene lower plasma triglyceride levels and reduce the incidence of coronary artery disease. LÄS MER

  5. 4. Adipose tissue mitchondrial function is modulated by antioxidants

    Författare :Eduard Peris Franquet; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocyte; metabolism; browning; antioxidant; mitochondria; oxidative stress; adrenergic recpetor; N-acetylcysteine; glutathione; reactive oxygen species;

    Sammanfattning : Antioxidants are widely used as reactive oxygen species (ROS) scavenging agents in experimental research and in conditions where oxidative stress plays a primary role. However, the effect of antioxidant supplementation on white and brown adipose tissue functionality is understudied, and the role of ROS and/or antioxidant treatment during adipose tissue browning, a process in which the adipocytes’ mitochondrial density and activity increase, is largely unknown. LÄS MER

  7. 5. Multifunctional carbohydrate-based soft materials from cereal by-products

    Författare :Secil Yilmaz Turan; Francisco Vilaplana; Rosana Moriana; Amparo Jiménez Quero; Anna Ström; KTH; []
    Nyckelord :wheat bran; corn bran; hemicellulose; arabinoxylan; ferulic acid; subcritical water extraction; acetylation; films; hydrogels; crosslinking; regeneration; antioxidant activity; vetekli; majskli; hemicellulosa; arabinoxylan; ferulsyra; subkritisk vattenextraktion; acetylering; filmer; hydrogeler; tvärbindning; regeneration; antioxidant aktivitet; Bioteknologi; Biotechnology;

    Sammanfattning : Cereal production generates large quantities of by-products every year, which still remain underutilized. The hemicellulose fractions from cereal by-products are anticipated to play an important role in tomorrow's sustainable and bio-based circular economy. LÄS MER