Sökning: "Mitosis"

Visar resultat 21 - 25 av 112 avhandlingar innehållade ordet Mitosis.

1. 21. Chemical induction of spindle disturbances and abnormal chromosome numbers in cultured mammalian cells

   Författare :Agneta Önfelt; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Early investigations have shown that many chemically different compounds can cause spindle disturbances in eukaryotic cells and that there is an unspecific (physical) mechanism based on the partitioning of the compound into cellular hydrophobic compartments. This suggests that the approach should be quantitative when testing compounds for spindle disturbing activity in vitro; effect/no effect is not the most pertinent question. LÄS MER

3. 22. Interactive antiproliferative mechanisms when 5-fluorouracil is combined with cisplatin or ionizing radiation : an in vivo and in vitro experimental study

   Författare :Urban D Nylén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Results from clinical studies and experimental investigations have given evidence of a synergistic effect when 5- fluorouracil (5-FU) has been combined with radiation or cisplatin (CDDP). From earlier experiments performed by the research team we know, that addition of S-FU to CDDP can synergistically increase the antiproliferative effect. LÄS MER

4. 23. Multifaceted roles of the transmembrane nuclear envelope protein, Samp1

   Författare :Mohammed Hakim Jaffer Ali; Einar Hallberg; Giovanna Lattanzi; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Nuclear envelope; transmembrane protein interaction studies; cell differentiation; stem cells; myopathies; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The eukaryotic nuclear envelope (NE), separates the nucleoplasm from cytoplasm and is made up of two concentric lipid membranes, the outer and the inner nuclear membranes (ONM and INM), the nuclear pore complexes (NPCs) and an underlying filamentous nuclear lamina. The INM contains hundreds of unique transmembrane proteins of which only a handful have been characterized. LÄS MER

5. 24. Single cell analysis of checkpoints in G1

   Författare :Hanna-Stina Martinsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cell cycle; restriction point; cyclin D; pRb; rRNA synthesis; cell growth; attachment;

   Sammanfattning : It is becoming evident that defective cell cycle regulation is an important property of the cancer cell. The restriction point (R), a G1 checkpoint after which cell cycle progression becomes independent of extracellular growth factors, is often aberrant in cancer cells. LÄS MER

7. 25. The functional organization of nuclear membrane proteins and development of new technology for studies of cell signaling

   Författare :Ricardo A. Figueroa; Einar Hallberg; Yosef Gruenbaum; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

   Sammanfattning : The eukaryotic cell is defined by the nucleus, which is delimited by a double membrane structure termed the nuclear envelope (NE). The NE is implicated in a multitude of different processes, for example chromatin organization. LÄS MER