Sökning: "Mitokondriell Medicin"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Mitokondriell Medicin.

  1. 1. Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells

    Författare :Fredrik Sjövall; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; sepsis; severe sepsis; septic shock; platelets; mitochondria; OXPHOS; high-resolution respirometry; mitochondrial disorders; multiple organ failure; biogenesis; leukocytes; cytokines; respirometry; oxygen consumption; blood cells; temporal;

    Sammanfattning : Sepsis is a devastating disease that is caused by the host’s response to an overwhelming infectious process. As sepsis progresses, organs distant from the site of infection become affected and sepsis-induced multiple organ failure ensues. LÄS MER

  3. 2. Effect of experimental complex III deficiency on respiratory chain assembly and function

    Författare :Mina Davoudi; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The assembly of respiratory chain complexes in the mitochondrial inner membrane requires specific factors. Once assembled to form a mature functional complex, complex III (CIII) is a dimer consisting of two monomers, each with eleven subunits. LÄS MER

  4. 3. The effect of different exercise regimens on mitochondrial biogenesis and performance

    Författare :Niklas Psilander; Kent Sahlin; Jostein Hallén; Gymnastik- och idrottshögskolan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin Teknik; Medicine Technology;

    Sammanfattning : Endurance training is a powerful tool to improve both health and performance. Physical activity is now recognized as an effective treatment and prevention therapy for a wide range of diseases. One of the most profound adaptations to endurance training is increased mitochondrial function and content within the exercising muscles. LÄS MER

  5. 4. Control of metabolism and hormone secretion from pancreatic alpha and beta cells

    Författare :Jelena Stamenkovic; Diabetes - molekylär metabolism; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLOCK genes; insulin; glucagon; metabolites; mitochondria; knock out;

    Sammanfattning : Type 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. LÄS MER

  7. 5. Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

    Författare :Anders H Olsson; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Genetics; Epigenetics; Human Pancreatic Islets; Oxidative Phosphorylation; Insulin Secretion;

    Sammanfattning : The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. LÄS MER