Sökning: "Mitochondrial disease"

Visar resultat 1 - 5 av 219 avhandlingar innehållade orden Mitochondrial disease.

  1. 1. Mitochondrial Evolution : Turning Bugs into Features

    Författare :Olof Karlberg; Siv Andersson; Michael Gray; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Biology; Biologi;

    Sammanfattning : The bacterial origin of mitochondria from an ancient endosymbiosis is now widely accepted and the mitochondrial ancestor is generally believed to belong to the bacterial subdivision α-proteobacteria. The high fraction of mitochondrial proteins encoded in the nucleus has commonly been explained with a massive transfer of genes from the genome of the ancestral mitochondrion. LÄS MER

  3. 2. Mitochondrial dysfunction and metabolic intervention

    Författare :Johannes Ehinger; Mitokondriell Medicin; []
    Nyckelord :Mitochondrial Diseases; Huntington Disease; Amyotrophic lateral sclerosis; Succinate; Neurodegenerative disease; Inborn errors of metabolism; Mitochondria; Animal models;

    Sammanfattning : .... LÄS MER

  4. 3. Mitochondrial monoamine oxidase : studies on its activity in some psychiatric diseases

    Författare :Åsa Wiberg; Umeå universitet; []
    Nyckelord :Monoamine oxidase; psychiatric disease; suicides; alcohol abuse; schizophrenica; cycloid psychoses;

    Sammanfattning : Monoamine oxidase (E.C.I.4. LÄS MER

  5. 4. Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse

    Författare :Sarah Piel; Klinisk neurofysiologi; []
    Nyckelord :mitochondria; drug-induced mitochondrial toxicity; mitochondrial disease; mitochondrial medicine; drug development; succinate; methylene blue; metformin; acetaminophen; paracetamol; Kolliphor® EL;

    Sammanfattning : Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. LÄS MER

  7. 5. Mitochondria in Alzheimer's Disease : The Presequence Protease and Mitochondria-Associated ER Membranes

    Författare :Catarina Moreira Pinho; Elzbieta Glaser; Paolo Bernardi; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s Disease; Mitochondria; Mitochondria-associated ER membranes; human Presequence Protease; Biochemistry; biokemi;

    Sammanfattning : Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders and the accumulation of the amyloid-β peptide (Aβ) in the temporal lobe has been implicated in the pathology of AD. Synaptic transmission in neuronal cells is a highly energy dependent process, which relies on the presence and proper function of mitochondria. LÄS MER