Sökning: "Misfolding"

Visar resultat 1 - 5 av 57 avhandlingar innehållade ordet Misfolding.

  1. 1. Protein Misfolding in Human Diseases

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Karin Almstedt; Linköpings universitet.; Linköpings universitet.; [2009]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Misfolding; carbonic anhydrase; prion protein; protein stability; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Sammanfattning : There are several diseases well known that are due to aberrant protein folding. These types of diseases can be divided into three main categories: Loss-of-function diseases Gain-of-toxic-function diseases Infectious misfolding diseases   Most loss-of-function diseases are caused by aberrant folding of important proteins. LÄS MER

  2. 2. Zinc in folding and misfolding of SOD1 Implications for ALS

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Lina Leinartaité; Stockholms universitet.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein misfolding; local unfolding; metal binding; energy landscape; protein disease; amyotrophic lateral sclerosis; biokemi; Biochemistry;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing degeneration of upper and lower motor neurons. Most ALS cases are sporadic; only 6% are associated with mutations in Cu, Zn superoxide dismutase (SOD1). LÄS MER

  3. 3. Fluorescent Probes and Protein Misfolding: Methods and Applications

    Detta är en avhandling från Department of Biochemistry and Structural Biology, Lund University

    Författare :Irem Nasir; Lunds universitet.; Lund University.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; fluorophores; filter-trap; site-specific fluorophore labeling; amyloid-beta; microscopic rate constants; solvatochromic probes; alpha-synuclein; lipid vesicles; nanoparticles; protein adsorption;

    Sammanfattning : Popular Abstract in English Proteins are smart molecules. They act in a vast variety of roles, for instance as transporters, messengers, catalysts, warriors and scaffolds. The ability of a specific protein to perform a task is closely related to its three-dimensional shape (native fold). LÄS MER

  4. 4. SOD1 Aggregation Relevance of thermodynamic stability

    Detta är en avhandling från Department of Biochemistry and Biophysics, Stockholm University

    Författare :Lisa Lang; Stockholms universitet.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aggregation; misfolding; Superoxide dismutase SOD1 ; Amyotrophic lateral sclerosis ALS ; unfolding; thermodynamic stability; biokemi; Biochemistry;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the upper and lower motor neurons causing muscle atrophy and paralysis followed by death. Aggregates containing superoxide dismutase (SOD1) are found as pathological hallmark in diseased ALS patients. LÄS MER

  5. 5. Molecular Aspects of Transthyretin Amyloid Disease

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Karin Sörgjerd; Linköpings universitet.; Linköpings universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid; apoptosis; BiP; chaperone; misfolding; oligomer; transthyretin; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi;

    Sammanfattning : This thesis was made to get a deeper understanding of how chaperones interact with unstable, aggregation prone, misfolded proteins involved in human disease. Over the last two decades, there has been much focus on misfolding diseases within the fields of biochemistry and molecular biotechnology research. LÄS MER