Sökning: "Minocycline"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet Minocycline.

  1. 1. Nanoparticle-based drug delivery systems for neural interfaces - a novel approach for improved biocompatibility

    Författare :Alexander Dontsios Holmkvist; Neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Neural interfaces; brain damage injury; Minocycline; Gelatin; Nanoparticles; Drug-delivery systems; Biocompatibility; Tissue responses; immunohistochemistry IHC ; Poly D; L-lactic-co-glycolic acid PLGA ; Hydrophobic ion paring; Emulsification-solvent-diffusion method; Drug release; Microglia activation;

    Sammanfattning : The overall purpose of this thesis was to reduce brain tissue responses around implanted microelectrodes using a pharmacological strategy. One of the main aims was to develop and evaluate drug delivery systems that allow local administration of anti-inflammatory pharmaceutics. LÄS MER

  3. 2. On antimicrobial approaches to arrest and control chronic periodontitis

    Författare :Maj-Karin Hellström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Plaque control; microorganisms; magnolia; dentifrice; gingivitis; PVP iodine; maintenanc; tetracycline; minocycline;

    Sammanfattning : The main objectives were to study the effect of frequently repeated supragingival plaque removal on the subgingival microbiota and periodontal pocket reduction and to analyze the adjunctive effect of different antimicrobial agents on the treatment of periodontal disease. Subjects with gingivitis or chronic periodontitis were included. LÄS MER

  4. 3. Death mechanisms compromising hippocampal neurogenesis after status epilepticus

    Författare :Christine Ekdahl Clementson; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; minocycline; lipopolysaccharide; microglia activation; status epilepticus; epilepsy; cysteinyl aspartate-specific proteases; apoptosis; neurogenesis; progenitor cell progeny;

    Sammanfattning : Status epilepticus (SE) leads to neurodegeneration as well as neurogenesis in the adult rat hippocampus. This thesis demonstrates that even if the neurogenic response initially is very pronounced, with a several-fold increase in cell proliferation, the survival of the newly formed neurons is compromised by a death mechanism involving mitochondria-related caspases. LÄS MER

  5. 4. Calcium-induced mitochondrial permeability transition in CNS-derived mitochondria - Pharmacological aspects of specificity and toxicity in neuroprotection

    Författare :Roland Månsson; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; mitochondria; brain; calcium; respiration; cell death; permeability transition; calcium retention; minocycline; neuroprotection; Debio 025;

    Sammanfattning : Mitochondria are the main site for energy conversion in the cell. Under certain circumstances, such as excess calcium retention or production of reactive oxygen species, a pore forms at contact sites between the outer and the normally impermeable inner mitochondrial membrane. LÄS MER

  7. 5. Role of spinal and peripheral HMGB1 in arthritis-induced pain

    Författare :Nilesh Mohan Agalave; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic pain is one of the most debilitating and repeatedly reported symptoms by rheumatoid arthritis (RA) patients. Despite good disease control achieved with disease modifying antirheumatic drugs (DMARDs), joint pain remains a major problem for a subgroup of patients. LÄS MER