Sökning: "Mikael Oscarson"

Hittade 3 avhandlingar innehållade orden Mikael Oscarson.

  1. 1. Genetic polymorphism of human drug metabolising enzymes : structural and functional studies

    Författare :Mikael Oscarson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : There is a pronounced interindividual variability in the levels and activity of many drug metabolising enzymes, which might cause differences in the sensitivity to and the toxicity of many clinically used drugs as well as environmental compounds such as nicotine and precarcinogens. In the present investigation the molecular genetic basis for some of the differences in the CYP2A6, CYP2D6, CYP2E1 and GSTM1 enzymes have been elucidated. LÄS MER

  3. 2. Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses

    Författare :Susanne Johansson; Jan Kihlberg; Mikael Elofsson; Stefan Oscarson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sialic acid; sialylmimetics; sialylation; multivalency; glycoconjugates; adenovirus; antiviral agents; epidemic keratoconjunctivitis; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : The combat against viral diseases has been, and still is, a major challenge in the field of drug development. Viruses are intracellular parasites that use the host cell ma-chinery for their replication and release. Therefore it is difficult to target and destroy the viral particle without disturbing the essential functions of the host cell. LÄS MER

  4. 3. Synthesis of oligosaccharides related to the capsular polysaccharide of Neisseria meningitidis serotype A

    Författare :Peter Teodorovic; Stefan Oscarson; Mikael Elofsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Sammanfattning : In order to find suitable stable vaccine candidates against Neisseria meningitidis group A, several structures related to the capsular polysaccharide have been synthesised. The first part of the thesis describes the synthesis of C-phosphonate analogues starting from glucose. LÄS MER