Sökning: "Mikael Karlström"

Hittade 3 avhandlingar innehållade orden Mikael Karlström.

  1. 1. Structure determination, thermal stability and catalytic mechanism of hyperthermostable isocitrate dehydrogenases

    Författare :Mikael Karlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :X-ray crystallography; isocitrate dehydrogenase; thermostability; catalytic mechanism;

    Sammanfattning : In this thesis, studies on the enzyme isocitrate dehydrogenase (IDH) from the hyperthermophiles Aeropyrum pernix (ApIDH), Thermotoga maritima (TmIDH), Archaeoglobus fulgidus (AfIDH) and Pyrococcus furiosus (PfIDH) are presented. The aim of the described work was to contribute to the understanding of protein thermostability and to study the catalytic mechanism. LÄS MER

  3. 2. Heart failure : biomarker effect and influence on quality of life

    Författare :Patric Karlström; Urban Alehagen; Mikael Dellborg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heart failure; Biomarker; B-type natriuretic peptide; Heart failure treatment; B-type Natriuretic Peptide guided heart failure treatment; Responders; Health-related quality of life; Heart failure duration; Outcomes;

    Sammanfattning : Background and aims: Heart failure (HF) is a life threatening condition and optimal handling is necessary to reduce risk of therapy failure. The aims of this thesis were: (Paper I) to examine whether BNP (B-type natriuretic peptide)-guided HF treatment improves morbidity and mortality when compared with HF therapy implemented by a treating physician at sites experienced in managing patients with HF according to guidelines; (Paper II) to investigate how to define a responder regarding optimal cut-off level of BNP to predict death, need for hospitalisation, and worsening HF and to determine the optimal time to apply the chosen cut-off value; (Paper III) to evaluate how Health-Related Quality of Life (HR-QoL) is influenced by natriuretic peptide guiding and to study how HR-QoL is affected in responders compared to non-responders; (Paper IV) to evaluate the impact of patient age on clinical outcomes, and to evaluate the impact of duration of the HF disease on outcomes and the impact of age and HF duration on BNP concentration. LÄS MER

  4. 3. Extended impregnation kraft cooking of softwood : Effects on reject, yield, pulping uniformity, and physical properties

    Författare :Katarina Karlström; Mikael E. Lindström; Elisabet Brännvall; Kristofer Gamstedt; Anna Jacobs; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; high kappa number pulp; extended impregnation; softwood; spruce; picea abies; pine; pinus sylvestris; uniform delignification; kappa number distribution; reject; yield; tensile index; tensile stiffness index; SCT; starch multilayers; mechano-sorptive creep; hygroexpansion; dimensional stability; eucalypt; birch; acacia; Cellulose and paper engineering; Cellulosa- och pappersteknik;

    Sammanfattning : Converting wood into paper is a complex process involving many different stages, one of which is pulping. Pulping involves liberating the wood fibres from each other, which can be done either chemically or mechanically. LÄS MER