Sökning: "Microtissues"
Hittade 3 avhandlingar innehållade ordet Microtissues.
1. Strength in Numbers – Droplet Microfluidics for Multicellular Ensemble Applications
Sammanfattning : The work presented in this doctoral thesis explores multicellular, biological, and biotechnological applications for microfluidic droplets, making use of a number of unique features of these miniaturized, highly scalable reaction vessels.Droplet microfluidics specializes in pico- to nanoliter sized aqueous droplets in an immiscible oil phase, borrowing techniques from the field of microfluidics, namely fluid actuation, detection systems and electronic peripherals. LÄS MER
2. Development of therapeutic strategies for quiescent tumor cell populations
Sammanfattning : Phenotypic screening is an effective approach to the discovery of small-molecule drugs. In this thesis, I have used cancer cells grown as 3D microtissues (multicellular spheroids) to study the effect of anticancer drugs and as drug discovery tools. LÄS MER
3. Modelling of steatosis and insulin resistance development in human hepatic 3d spheroids : mechanisms and genetic aspects
Sammanfattning : Hepatic steatosis and insulin resistance are common disease manifestations seen in metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) patients. Aberrant hepatic lipid accumulation leads to both morphological changes and metabolic alterations in liver function and may cause serious end-stage liver disease. LÄS MER