Sökning: "Microsatellite Instability"

Visar resultat 16 - 20 av 32 avhandlingar innehållade orden Microsatellite Instability.

1. 16. Gut microbiota in colorectal cancer : The importance of Parvimonas micra

   Författare :Thyra Löwenmark; Richard Palmqvist; Sofia Edin; Pär Larsson; Michael Dahlberg; Per Hellström; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; mucosal microbiota; Parvimonas micra; Fusobacterium nucleatum; immunity; survival; biomedical laboratory science; biomedicinsk laboratorievetenskap;

   Sammanfattning : Colorectal cancer (CRC) is a heterogenous disease consisting of multiple molecular subtypes, each of which has diverse treatment responses and prognoses. The importance of the gut microbiota in CRC development and progression has undergone increasing recognition in recent years, with a structural segregation in terms of microbial composition between CRC patients and healthy controls. LÄS MER

3. 17. Molecular genetics of hereditary non-polyposis colorectal cancer

   Författare :Pia Tannergård; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Colorectal cancer (CRC) is one of the most prevalent malignancies in the Western World and one of the most predominant causes of death by cancer. There is a subgroup of syndromes with a high incidence of CRC which is transmitted in an autosomal dominant fashion. LÄS MER

4. 18. Morphological Features and Mismatch Repair in Colorectal Tumors

   Författare :Britta Halvarsson; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; patologisk anatomi; Lynch syndrome; Colorectal tumors; HNPCC; Mismatch repaire; pathological anatomy; General pathology; Genetik; cytogenetik; cytogenetics; Genetics; Medicin människa och djur ; Medicine human and vertebrates ; Immunohistochemistry;

   Sammanfattning : Corlorectal cancer affects 5% of individuals in the Western world and heredity is estimated to cause at least 10% of the tumors. Defective mismatch repair (MMR) is a tumorigenic mechanism through which about 15% of colorectal cancer develops and this feature characterizes tumors associated with Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch syndrome. LÄS MER

5. 19. Genetic and epidemiological studies of hereditary colorectal cancer

   Författare :Kristina Cederquist; Henrik Grönberg; Irina Golovleva; Gösta Holmgren; Mef Nilbert; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Lynch syndrome; HNPCC; colorectal cancer; endometrial cancer; cancer risk; MSI; MLH1; MSH2; MSH6; genome-wide scan; Genetik; Clinical genetics; Klinisk genetik; medicinsk genetik; Medical Genetics;

   Sammanfattning : Lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer, HNPCC) is the most common hereditary syndrome predisposing to colorectal cancer, accounting for 1-3% of all colorectal cancer. This multi-organ cancer predisposition syndrome is caused by mutations in the mismatch repair (MMR) genes, especially MLH1 and MSH2, and to lesser extents MSH6 and PMS2, which lead to widespread genetic instability and thus microsatellite instability (MSI). LÄS MER

7. 20. Targeting allelic loss in colorectal cancer

   Författare :Verónica Rendo; Tobias Sjöblom; Nickolas Papadopoulos; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; gene editing; loss of heterozygosity; targeted therapy; whole genome sequencing;

   Sammanfattning : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. LÄS MER