Sökning: "Microarray"

Visar resultat 21 - 25 av 601 avhandlingar innehållade ordet Microarray.

  1. 21. Essays on spatial point processes and bioinformatics

    Författare :Jessica Fahlén; Patrik Rydén; Xavier de Luna; Yudi Pawitan; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Coverage process; vacancy; microarray; pre-processing; sensitivity; bias; dye-normalization; FFPE; storage time effects; Statistics; Statistik; Statistics; statistik;

    Sammanfattning : This thesis consists of two separate parts. The first part consists of one paper and considers problems concerning spatial point processes and the second part includes three papers in the field of bioinformatics. LÄS MER

  3. 22. Hypoxic gene regulation and oncogenic pathways in neuroblastoma

    Författare :Erik Fredlund; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microarray; hypoxia; MYCN; gene expression analysis; Neuroblastoma; Myc; pathway analysis; differentiation;

    Sammanfattning : Neuroblastoma patients show remarkable clinical heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates to aggressive disease. LÄS MER

  4. 23. Protein Microarrays Based on Single Framework Recombinant Antibody Fragments (SINFABS) - Catcher and Carrier - A Crucial Combination

    Författare :Cornelia Steinhauer; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; probe; coupling chemistry; solid support; stability; scFv; antibody microarray; protein microarray; Biotechnology; Bioteknik;

    Sammanfattning : Antibody-based microarrays are among the novel class of rapidly evolving proteomic technologies. In recent years, antibody microarrays have emerged as a unique tool for high-throughput protein expression profiling with great promise within biomedicine and a wide range of potential applications, including disease diagnostics and biomarker discovery. LÄS MER

  5. 24. Mining the transcriptome - methods and applications

    Författare :Valtteri Wirta; Joakim Lundeberg; John Quackenbush; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; transcriptome; gene expression profiling; EST; microarray; RNA amplification; stem cells; neurosphere; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Sammanfattning : Regulation of gene expression occupies a central role in the control of the flow of genetic information from genes to proteins. Regulatory events on multiple levels ensure that the majority of the genes are expressed under controlled circumstances to yield temporally controlled, cell and tissue-specific expression patterns. LÄS MER

  7. 25. Molecular Screening for Target Discovery in Cancer

    Författare :Mårten Fryknäs; Anders Isaksson; Ulf Pettersson; Hugh Salter; Uppsala universitet; []
    Nyckelord :Genetics; Cancer; Drug resistance; Microarray; High-throughput screening; Genetik;

    Sammanfattning : Cancer is one of the major causes of death in the western world. Resistance to anti-cancer drugs and diagnostic difficulties are major obstacles to successful treatment. LÄS MER