Sökning: "Michael Laub"

Hittade 2 avhandlingar innehållade orden Michael Laub.

  1. 1. Home Mechanical Ventilation in Sweden. Demography, Indications, Clinical Effects and Survival

    Författare :Michael Laub; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; home mechanical ventilation; Andningsorganen; Respiratory system; causes of death; selection criteria; clinical effects; prevalence; temporal changes; survival; Chronic respiratory failure hypoventilation;

    Sammanfattning : Home mechanical ventilation in patients with chronic respiratory failure secondary to several different diseases has become widely acceptable as the provision of ventilatory support can provide symptomatic relief and increase life expectancy. Aims: To study the selection criteria underlying the initiation of home mechanical ventilation and to quantify the effects of in relation to blood gases and lung function; to examine temporal changes in treatment prevalence in Sweden; to study survival and causes of death and demonstrate possible related impact factors. LÄS MER

  3. 2. Novel RelA-SpoT Homolog toxin-antitoxin systems that inhibit bacterial growth through production of toxic alarmone ppApp

    Författare :Steffi Jimmy; Vasili Hauryliuk; Vicky Shingler; Michael T. Laub; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; p ppGpp; ppApp; toxin; antitoxin; alarmone; antibacterials; molekylärbiologi; Molecular Biology; Biochemistry; biokemi;

    Sammanfattning : The stress alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively known as (p)ppGpp, are the molecular mediators of the bacterial stringent response — a bacterial stress response implicated in virulence, antibiotic tolerance and biofilm formation. At high concentrations, (p)ppGpp halts bacterial growth, inhibits protein synthesis and rewires transcription and metabolism. LÄS MER