Sökning: "Michael Holers"

Hittade 1 avhandling innehållade orden Michael Holers.

1. 1. IgM and Complement in Regulation of Antibody Responses

   Författare :Anna Sörman; Birgitta Heyman; Michael Holers; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG; GC responses; feedback regulation; T-cell responses; antigen presentation; complement receptors 1 and 2; Immunologi; Immunology;

   Sammanfattning : Animals deficient in complement components C1q, C4, C3, and CR1/2 have severely impaired antibody responses. C1q is primarily activated by antibody-antigen complexes. Antigen-specific IgM in complex with an antigen is able to enhance the antibody response against that antigen. This is dependent on the ability of IgM to activate complement. LÄS MER