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1. 1. Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA

   Författare :Mia Bjerke; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Nucleoside analogs are modified nucleosides used in treatment of cancer and viral infections. They are dependent on intracellular phosphorylation to be pharmacologically active. Deoxyribonucleoside kinases catalyze the rate-limiting step in the phosphorylation of many clinically used nucleoside analogs. LÄS MER