Sökning: "Metalloproteinase"

Visar resultat 1 - 5 av 102 avhandlingar innehållade ordet Metalloproteinase.

1. 1. Biomolecular Aspects of Flexor Tendon Healing

   Författare :Maria Berglund; Monica Wiig; Olof Nilsson; Jan Fridén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Flexor tendon healing; Growth factor; Metalloproteinase; Collagen; Proteoglycan; Myofibroblast; Hyaluronan synthase; Mast cell; Hand surgery; Handkirurgi; Orthopaedics; Ortopedi;

   Sammanfattning : Flexor tendon injuries in zone II of the hand (i.e. between the distal volar crease and the distal interphalangeal joint) can be costly for both the afflicted individual and society because of the high cost of a long rehabilitation period, complicated by tendon ruptures or scarring with adhesion formation, causing impaired range of motion. LÄS MER

3. 2. Injury-induced activation of vascular smooth muscle cells. Role of specific gene expression and intracellular signalling pathways

   Författare :Cecilia Lövdahl; Reumatologi och molekylär skelettbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metalloproteinase; extracellular matrix; ERK1 2 signalling; migration; proliferation; injury; vessel wall; smooth muscle cell; Medicine human and vertebrates ; Medicin människa och djur ;

   Sammanfattning : Migration and proliferation of smooth muscle cells (SMC) are important events in the development of atherosclerosis and restenosis following angioplastic surgery. It is important to gain further knowledge about the mechanisms regulating SMC form and function in order to understand the underlying disease process. LÄS MER

4. 3. Impact of autocrine factors on physiology and productivity in Trichoplusia ni serum-free cultures

   Författare :Ulrika Eriksson; Lena Häggström; Per Berglund; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biotechnology; Trichoplusia ni; High Five; insect cells; BEVS; serum-free medium; yeast extract; conditioned medium; autocrine regulation of proliferation; growth factors; cell cycle; metalloproteinase; specific productivity; Bioteknik; Bioengineering; Bioteknik;

   Sammanfattning : The aim of this study was to increase the understanding of the mechanisms regulating cell proliferation and recombinant protein production in serum-free cultures of Trichoplusia ni (T. ni) insect cells.Conditioned medium (CM) was shown to contain both stimulatory and inhibitory factors (CM factors) influencing cell growth. LÄS MER

5. 4. Towards surgical use of matrix metalloproteinase biology

   Författare :Björn Pasternak; Per Aspenberg; Pentti Tengvall; Yrjö T Konttinen; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; colon; tetracyclines; tissue inhibitor of metalloproteinases TIMP ; wound healing.; colorectal surgery; extracellular matrix; humans; matrix metalloproteinases MMPs ; rats; surgical anastomosis; sutures; tendon injuries; Orthopaedics; Ortopedi;

   Sammanfattning : Matrix metalloproteinases (MMPs), such as collagenases, are a family of enzymes capable of degrading most constituents of the extracellular matrix. MMPs are thought to be involved in the aetiopathogenesis of tendon rupture. Additionally, failure of healing has in some instances been associated with elevated levels of MMPs. LÄS MER

7. 5. Skeletal muscle matrix metalloproteinase and exercise in humans

   Författare :Eric Rullman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Skeletal muscle is a highly plastic tissue; it has a great capacity to adapt to environmental demands throughout life. The structural and functional changes that occur in response to exercise training are well characterized whereas much less is known about these adaptive processes at the cellular and molecular levels. LÄS MER