Sökning: "Metabolomics"

Visar resultat 11 - 15 av 144 avhandlingar innehållade ordet Metabolomics.

1. 11. Development of Protocols for Metabolomics in Biomedical Research using Chemometrics

   Författare :Anders Danielsson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; gas chromatography; design of experiments; Metabolomics; chemometrics; diabetes; metabolism; multivariate analysis;

   Sammanfattning : Metabolomics is a rapidly growing research field. It aims for quantification of all the metabolites in a biological sample such as plasma, saliva, cerebrospinal fluid or cells. LÄS MER

3. 12. Multivariate profiling of metabolites in human disease : Method evaluation and application to prostate cancer

   Författare :Elin Thysell; Henrik Antti; Janne Lehtiö; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolite profiling; metabolomics; predictive metabolomics; mass spectrometry; GC-MS; biomarkers; chemometrics; design of experiments; multivariate data analysis; prostate cancer; bone metastases; plasma; biologisk kemi; biological chemistry;

   Sammanfattning : There is an ever increasing need of new technologies for identification of molecular markers for early diagnosis of fatal diseases to allow efficient treatment. In addition, there is great value in finding patterns of metabolites, proteins or genes altered in relation to specific disease conditions to gain a deeper understanding of the underlying mechanisms of disease development. LÄS MER

4. 13. Metabolomics of Weight Loss and Weight Maintenance in Obese Humans

   Författare :Nina Geidenstam; Diabetes - klinisk obesitasforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolomics; Obesity; Weight Loss; Weight Maintenance; OGTT; Metabolites; Insulin Resistance; Amino Acids;

   Sammanfattning : .... LÄS MER

5. 14. Statistics in Gene Expression, Metabolomics, and Comparative Genomics in Evolution

   Författare :Alexandra Jauhiainen; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene Expression; Metabolomics; Data Integration; Comparative genomics; Gene Expression;

   Sammanfattning : This thesis contains four papers concerning (I) the evolutionary conservation of drug targets and its potential use in environmental risk assessments, (II) RNA degradation as a control mechanism during osmotic stress in the yeast S. cerevisiae, (III) the localization and effects of the gene DDIT3 encoding a key regulator of stress response, and (IV) the integration and analysis of transcriptional and metabolic data to identify active metabolic pathways. LÄS MER

7. 15. Metabolite Alterations and Cardiometabolic Disease: A Nutritional Perspective

   Författare :Einar Smith; Kardiovaskulär forskning - hypertoni; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolomics; Nutrition; Nutritional metabolomics; Biomarkers; Cardiometabolic disease; Cardiovascular disease; Type 2 diabetes; Prospective cohort studies; Dietary intervention;

   Sammanfattning : Background Cardiovascular disease (CVD), type 2 diabetes (T2DM), and atrial fibrillation (AF) collectively impact millions globally, necessitating a comprehensive understanding of preceding metabolic alterations for early intervention. This thesis aims to explore metabolic shifts across populations-based cohorts and evaluate the metabolic impact of a dietary intervention. LÄS MER