Sökning: "Metabolites"
Visar resultat 1 - 5 av 760 avhandlingar innehållade ordet Metabolites.
1. Progesterone metabolites : learning, tolerance, antagonism & metabolism
Sammanfattning : Progesterone metabolites as allopregnanolone, isoallopregnanolone and tetrahydrodeoxy-corticosterone (THDOC) are increased in the luteal phase of the menstrual cycle, throughout pregnancy and during stress. Allopregnanolone and THDOC are neurosteroids with 3α-hydroxy, 5α-configurations and positive modulating effect on the GABAA receptor. LÄS MER
2. Drug Metabolites Formed by Cunninghamella Fungi : Mass Spectrometric Characterization and Production for use in Doping Control
Sammanfattning : This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. The metabolites were characterized with mainly liquid chromatography-mass spectrometry using ion-trap and quadrupole-time-of-flight instruments. A fungal in vitro model has several advantages e.g. LÄS MER
3. Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites
Sammanfattning : Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). LÄS MER
4. Volatile metabolites from microorganisms in indoor environments : sampling, analysis and identification
Sammanfattning : Microorganisms are able to produce a wide variety of volatile organic compounds. This thesis deals with sampling, analysis and identification of such compounds, produced by microorganisms commonly found in buildings. LÄS MER
5. Polychlorinated biphenyls and their metabolites in human blood : Method development, identification and quantification
Sammanfattning : PCBs are well known environmental pollutants. They are also precursors to metabolites, as the hydroxy-PCBs and the methylsulfonyl-PCBs. This thesis presents a validated methodology for analysis of PCB metabolites and a structural identification of 38 hydroxy-PCBs in human blood. LÄS MER