Sökning: "Metabolic activation"
Visar resultat 36 - 40 av 293 avhandlingar innehållade orden Metabolic activation.
36. Cardiovascular, behavioural and metabolic consequences of growth hormone overexpression in transgenic mice
Sammanfattning : Growth hormone (GH) exerts major effects on body growth and metabolism. GH is also important in controlling cardiovascular function and behaviour. To study the role of growth hormone in cardiovascular function and regulation of blood pressure, we overexpressed bovine growth hormone regulated by the metallothionein promoter in mice (Mt-bGH). LÄS MER
37. Genetic and metabolic studies towards personalized conditioning regimen prior to stem cell transplantation
Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non- malignant diseases. The busulphan (Bu)/cyclophosphamide (Cy) combination is one of the most common conditioning regimens given prior to HSCT. LÄS MER
38. Structural, functional and metabolic effects of growth hormone on nomal and failing heart
Sammanfattning : The growth hormone/insulin-like growth factor I (GH/IGF-I) system plays an important role for cardiac development, structure and function. Recently, data from experimental and clinical studies have suggested the use of GH as treatment after myocardial infarction (MI) affecting cardiac remodeling and development of heart failureThe aim of this thesis was to study the effects of GH on cardiac structure, function and energy metabolism in normal and failing heart. LÄS MER
39. Diabetogenic effects of glucocorticoids : role of protein phosphatase 5 and GLP-1 receptor activation
Sammanfattning : Obesity, the metabolic syndrome and type 2 diabetes are inextricably linked together, and all increase with rapid pace globally. Glucocorticoid (GC) excess is associated with diabetogenic effects, including insulin resistance and glucose intolerance, and a role for GCs has also been proposed in the development and pathology of the metabolic syndrome. LÄS MER
40. Tissue- and site-specific effects of PPARγ activation and its role in chronic inflammation
Sammanfattning : Developmental programming, metabolism, immune function and tissue homeostasis in multicellular organisms are regulated by a plethora of stimuli. Transcription factors (TFs) convert incoming signals to appropriate transcriptional responses of the genome. LÄS MER