Sökning: "Merkel cell"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Merkel cell.

  1. 1. Epidemiology, diagnostics and treatment of non-melanoma skin cancers

    Författare :Oscar Zaar; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; non-melanoma skin cancer; basal cell carcinoma; merkel cell carcinoma; Bowen’s disease; imaging mass spectrometry; lipidomics; photodynamic therapy;

    Sammanfattning : Skin cancer, including malignant melanoma and non-melanoma skin cancer (NMSC), is a growing problem due to the increasing incidence in Sweden and in other Caucasian populations. NMSCs are diagnosed as often as all other cancers combined and include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), precursors to SCC such as Bowen’s disease (BD) and actinic keratosis (AK), as well as several rare skin cancers including Merkel cell carcinoma (MCC). LÄS MER

  3. 2. Dissecting the roles of viral T-antigens in Merkel cell carcinoma

    Författare :Jiwei Gao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Merkel cell carcinoma (MCC) is a rare but aggressive form of skin malignancy with increasing incidence. Merkel cell polyomavirus (MCPyV) is associated with ~80% of MCCs, and a minority is caused by ultra-violet (UV)-induced DNA damage. The MCPyV T-antigens are major drivers for MCC oncogenesis. LÄS MER

  4. 3. Connecting viral oncoproteins to microRNA, autophagy and metabolism in Merkel cell carcinoma

    Författare :Satendra Kumar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Merkel cell carcinoma (MCC) is an aggressive type of skin cancer. Around 80% of MCCs harbor an integrated Merkel cell polyomavirus (MCPyV) genome with a mutation in the large T antigen (LT) gene, leading to expression of truncated LT. It is evident that the viral truncated LT and small T antigen (sT) play important roles in MCC tumorigenesis. LÄS MER

  5. 4. Studies on polyomaviruses in humans : in relation to haematopoietic stem cell transplantation and cancer

    Författare :Géraldine Giraud; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The simultaneous discovery of two polyomaviruses in humans in 1971, BK and JC viruses (BKV and JCV), initiated the research on polyomaviruses in relation to human diseases. This has now been intensified with the consecutive discoveries, the last three years, of three new family members, KI, WU and Merkel cell polyomaviruses (KIPyV, WUPyV and MCPyV). LÄS MER

  7. 5. Studies on nerve terminations in human mucosa and skin

    Författare :Marita Hilliges; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Epithelium; herpes simplex; immunohistochemisry; Merkel cell; mucosa; nerves; oral; PGP 9.5; skin; stereology; urinary incontinence; vagina.;

    Sammanfattning : In spite of their accessibility and important sensory function, the nervous tissue components of human oral and vaginal mucosa and skin have been subject to very few, if any, systematic investigations. Studies on the innervation of oral tissues have mainly focused on the dental pulp, the periodontium and the gingiva, probably because of specific clinical interest, thus largely neglecting the mucosa. LÄS MER