Sökning: "Megakaryocyte"
Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet Megakaryocyte.
1. Sources of Arachidonic Acid in Platelets, Bone, Marrow and Gastrointestinal Tract
Sammanfattning : This study investigates pathways by which the eicosanoid precursor pools in the platelets, bone marrow and the gastrointestinal (GI) mucosa are acquired and regulated, and in this context some aspects on the interaction between triglyceride (TG)-rich lipoproteins and platelets. 1. LÄS MER
2. Programming Blood Cell Fates. Insights from Direct Lineage Conversion and Development
Sammanfattning : Red blood cells (RBC) and platelets constitute the non-immune branch of the hematopoietic system and are responsible for the vital functions of transporting oxygen to the tissues and clotting blood vessel injuries, respectively. These cells are produced during embryonic development and throughout life through a process called hematopoiesis which is tightly regulated by extrinsic and intrinsic factors. LÄS MER
3. Angiogenesis in myeloproliferative disorders
Sammanfattning : The chronic myeloproliferative disorders, comprising polycythemia vera (PV), essential thrombocytosis (ET), chronic myeloid leukaemia (CML) and myelofibrosis (MF), are all characterized by pathological angiogenesis in variable degrees, e.g. increased microvascular density (MVD) and bizarre vessel architecture. LÄS MER
4. Characterization of human myeloid progenitors and their differentiation
Sammanfattning : All hematopoietic cells are derived from the hematopoietic stem cells (HSCs) in a continuous and dynamic process, regulated by a network of transcription factors in different combinations and extrinsic signals from growth factors (GFs) and other factors in the microenvironment. In the initial stages of hematopoiesis HSCs differentiate to progenitor cells with gradually more restricted lineage potential and according to the most accepted model the first restriction in developmental potential results in commitment to either the lymphoid or the myeloid branch, in the latter followed by commitment to the neutrophil/monocyte and erythrocyte/megakaryocyte lineages. LÄS MER
5. Hematopoietic stem cells: c-mpl and TNF receptor function
Sammanfattning : Hematopoietic stem cells (HSC) are crucial to life. Daily and throughout the life span of an individual they are responsible for replacing approximately 10(12) mature blood cells. Mature cells are, for example, required for transportation of oxygen, defense against infections and to stop bleeding. LÄS MER