Sökning: "Medicinska Fakulteten Umeå Universitet"

Visar resultat 1 - 5 av 103 avhandlingar innehållade orden Medicinska Fakulteten Umeå Universitet.

  1. 1. Yersinia-phagocyte interactions during early infection

    Författare :Linda Westermark; Maria Fällman; Joan Mecsas; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia; dendritic cell; macrophage; neutrophil; T3SS; Infectious Diseases; infektionssjukdomar;

    Sammanfattning : Pathogenic Gram-negative Yersinia species preferentially target and inactivate phagocytic cells of the innate immune defense by translocation of effector Yersinia outer proteins (Yops) into the cells via a type III secretion system. This indicates that inactivation and avoidance of the early innate immune response is an efficient way for Yersinia species to avoid elimination and to cause diseases ranging from mild gastroenteritis (Y. LÄS MER

  3. 2. RsbX and stress response in Listeria monocytogenes

    Författare :Ana Henriques de Oliveira; Jörgen Johansson; Cormac Gahan; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Listeria monocytogenes; SigB; stressosome; RsbX; phosphorylation; growth; competitiveness; motility; energetic cost; homeostasis; stress response; virulence; invasion; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

    Sammanfattning : Listeria monocytogenes is a ubiquitous foodborne Gram-positive bacterium. Despite being mainly a soil bacterium, it can reach the food processing environment and contaminate food destined for human consumption, causing outbreaks. LÄS MER

  4. 3. Malaria and relapsing fever Borrelia : interactions and potential therapy

    Författare :Jenny Lundqvist; Cathrine Persson; Antonio Barragan; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malaria; Plasmodium; relapsing fever; Borrelia; persistent; concomitant infections; polyamines; Molecular biology; Molekylärbiologi; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar; molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ; Infectious Diseases; infektionssjukdomar;

    Sammanfattning : Infectious diseases such as malaria and relapsing fever borreliosis (RF), cause severe human mortality and morbidity in developing countries. Malaria, caused by Plasmodium spp. parasites, is estimated by the World Health Organization to cause 1.5-2. LÄS MER

  5. 4. The role and mechanism of ubiquitin system in innate immune regulation

    Författare :Swarupa Panda; Nelson O. Gekara; Fredrik Elgh; Anna Överby; Geert van Loo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; The ubiquitin system; Deubiquitinase; MYSM1; Innate immune regulation Toll-like receptor; RIG-l like receptors; Cytoplasmic DNA receptors; NOD-like receptors; Francisella tularensis; Immune subversion; molekylärbiologi; Molecular Biology;

    Sammanfattning : Pattern-recognition receptors (PRRs) include the cell surface or endosomal membrane localized Toll-like receptors (TLRs) and the cytoplasmic PRRs such as RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and cytoplasmic DNA receptors (CDRs). Triggering of PRRs culminates in the transcriptional induction of pro-inflammatory cytokines and type I interferons (IFNs) that coordinate protection against pathogens but require tight control to avert inflammatory diseases. LÄS MER

  7. 5. Regulatory roles of two small RNAs in the human pathogen Listeria monocytogenes and the evaluation of an alternative infection model

    Författare :Jonas Gripenland; Jörgen Johansson; Tom Geissmann; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small RNA; sRNA; Riboswitch; Listeria monocytogenes; ncRNA; PrfA; molekylärbiologi; Molecular Biology;

    Sammanfattning : Listeriosis is a potentially lethal disease caused by the Gram-positive facultative intracellular pathogen Listeria monocytogenes (L.m.). L. LÄS MER