Sökning: "Medicinsk cellbiologi"

Visar resultat 11 - 15 av 363 avhandlingar innehållade orden Medicinsk cellbiologi.

  1. 11. Disturbed Islet Function and Alterations in Islet Protein Expression

    Författare :Henrik Ortsäter; Peter Bergsten; Franz Schuit; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; islet; glucose; oleate; corticosterone; oxygen tension; insulin release; protein profiling; Clark-like electrodes; SELDI-TOF MS; PPI-B; 11β-HSD1; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : Pancreatic β-cells sense the concentration of glucose in the systemic circulation through metabolism of the sugar molecule. Failure to correlate the blood sugar concentration to an appropriate metabolic signal disrupts the function of the β-cell as a controller of glucose homeostasis and may contribute to the development of type 2 diabetes mellitus. LÄS MER

  3. 12. Regulation of Phospholipase C and Plasma Membrane Phosphatidylinositol 4,5-bisphosphate in Insulin-Secreting Cells

    Författare :Sophia Thore; Anders Tengholm; Erik Gylfe; Peter Jones; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; PLC; PIP2; insulin-secreting cell; Ca2 ; evanescent wave microscopy; phosphoinositide kinase; ATP ADP ratio; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is an important signaling molecule as substrate for the phospholipase C (PLC)-catalyzed formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol, and by directly regulating e.g. ion-channels, the cytoskeleton and vesicle trafficking in various types of cells. LÄS MER

  4. 13. Signal Transduction of Glucagon Secretion

    Författare :Elaine Vieira; Erik Gylfe; Lena Eliasson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; secretion; glucagon; store-operated channels; calcium; diabetes; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : Diabetes mellitus is a bihormonal disorder with hyperglycemia due to deficiency of insulin and hypersecretion of glucagon. To improve diabetes treatment it is important to clarify the signal transduction of glucagon secretion. LÄS MER

  5. 14. Pro- and anti-inflammatory regulation of β2 integrin signalling in human neutrophils

    Författare :Veronika Brodin Patcha; Eva Särndahl; Emmanuelle Caron; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; inflammation; neutrophils; signalling; integrins; Cell biology; Cellbiologi;

    Sammanfattning : The body is under constant attack from pathogens trying to slip by our immune defence. If the barrier is breached, invading pathogens enter the tissues and cause inflammation. During this process neutrophils, constituting the first line of defence, leave the bloodstream and seek out and kill the invading pathogens. LÄS MER

  7. 15. Genetic mechanisms regulating proliferation and cell specification in the Drosophila embryonic CNS

    Författare :Shahrzad Bahrampour; Stefan Thor; Jan-Ingvar Jönsson; Simon Sprecher; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The central nervous system (CNS) consists of an enormous number of cells, and large cellular variance, integrated into an elaborate network. The CNS is the most complex animal organ, and therefore its establishment must be controlled by many different genetic programs. LÄS MER