Sökning: "Medicin och hälsovetenskap Medicinska grundvetenskaper Farmakologi och toxikologi"
Visar resultat 1 - 5 av 251 avhandlingar innehållade orden Medicin och hälsovetenskap Medicinska grundvetenskaper Farmakologi och toxikologi.
1. Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders
Sammanfattning : Alcohol use disorder (AUD) is a complex disorder with multiple pathophysiological processes contributing to the initiation, progression and development of the disease state. AUD is a chronic relapsing disease with escalation of alcohol-intake over time in repeated cycles of tolerance, abstinence and relapse and hence, it is very difficult to treat. LÄS MER
2. Systemic and local regulation of experimental arthritis by IFN-α, dendritic cells and uridine
Sammanfattning : In this thesis, we have studied the immunological processes of joint inflammation that may be targets for future treatment of patients with arthritis. We focus on the immune-modulating properties of interferon-α (IFN-α) and uridine in experimental arthritis. LÄS MER
3. Studies on interfaces between primary and secondary hemostasis
Sammanfattning : Our conceptual understanding of hemostasis is still heavily influenced by outdated experimental models wherein the hemostatic activity of platelets and coagulation factors are understood and studied in isolation. Although perhaps convenient for researchers and clinicians, this reductionist view is negated by an ever increasing body of evidence pointing towards an intimate relationship between the two phases of hemostasis, marked by strong interdependence. LÄS MER
4. Behavioral effects of female sex steroid hormones : models of PMS and PMDD in Wistar rats
Sammanfattning : Background Animal models can be used to mimic human conditions of psychopathology, and also as pre-clinical models to evaluate candidate drugs. With hormonal treatment it is possible to produce behavior in the rat which corresponds to the mental symptoms of pre-menstrual syndrome (PMS), and pre-menstrual dysphoric disorder (PMDD). LÄS MER
5. Disinhibitory and aggressive behavior in the rat. Neurohumoral mechanisms
Sammanfattning : Effective pharmacological treatment for impulsive aggression and dysfunctional impulsive behavior is needed. These behavioral disturbences in man and impulsive-like and aggressive behavior in animals may involve serotonin (5-HT), noradrenaline (NA), GABAA receptors and steroid hormones, e.g. testosterone. LÄS MER