Sökning: "Medical Biochemistry"

Visar resultat 11 - 15 av 455 avhandlingar innehållade orden Medical Biochemistry.

  1. 11. The expression and regulation of hyaluronan synthases and their role in glycosaminoglycan synthesis

    Författare :Jonas Brinck; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; hyaluronan; glycosaminoglycans; CD44; growth factors; UDP-glucose dehydrogenase; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : The glycosaminoglycan hyaluronan is an essential component of the extracellular matrix in all higher organisms, affecting cellular processes such as migration, proliferation and differentiation. Hyaluronan is synthesized by a plasma membrane bound hyaluronan synthase (HAS) which exists in three genetic isoforms. LÄS MER

  3. 12. Transcriptional regulation of mouse ribonucleotide reductase

    Författare :Anna Elfving; Lars Thelander; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ribonucleotide reductase; promoters; cell cycle; transcriptional regulation; primer extension; protein purification; EMSA; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : All living organisms are made of cells and they store their hereditary information in the form of double stranded DNA. In all organisms DNA replication and repair is essential for cell division and cell survival. These processes require deoxyribonucleotides (dNTPs), the building blocks of DNA. LÄS MER

  4. 13. Roles of Heparan Sulfate in Amyloid-β Pathology and Hypoxia

    Författare :Elina Hjertström; Jin-ping Li; Ulf Lindahl; Sally Stringer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; Alzheimer s disease; Aβ; Proteoglycan; Heparanase; Amyloid; Hypoxia; Cancer; Spalax; Biochemistry; Biokemi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Heparan sulfate (HS) is a highly sulfated polysaccharide expressed on the cell surface and in the extracellular matrix, interacting with a large number of proteins. HS is implicated in human diseases, including different types of cancer and amyloid diseases such as Alzheimer's disease (AD). LÄS MER

  5. 14. The megalin receptor

    Författare :Göran Hjälm; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; calcium; parathyroid; gp330; megalin; LRP-2; LDL-receptor super family; endogenous retroviruse; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Ionized calcium is a major player in the living organism. Its importance in both intra- and extracellular mechanisms have been studied in a broad number of publications. LÄS MER

  7. 15. Decoding Heparan Sulfate

    Författare :Johan Kreuger; John T. Gallager; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Heparan sulfate; fibroblast growth factor; receptor; endostatin; angiogenesis; interaction; sequence; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Heparan sulfate (HS) is a polysaccharide of glycosaminoglycan type composed of alternating hexuronic acid [either glucuronic acid (GlcA) or iduronic acid (IdoA)] and glucosamine (GlcN) units that can be sulfated in various positions. HS binds to a large number of proteins and these interactions promote many biological processes, including cell adhesion and growth factor signaling. LÄS MER