Sökning: "Mechanistic modeling"

Visar resultat 1 - 5 av 83 avhandlingar innehållade orden Mechanistic modeling.

  1. 1. Mechanistic-Empirical Modeling of Permanent Deformation in Asphalt Concrete Layers

    Författare :Erik Oscarsson; Trafik och väg; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; permanent deformation; modeling; Mechanistic-Empirical; rutting; asphalt concrete; full-scale pavements;

    Sammanfattning : Three mechanistic-empirical permanent deformation models were evaluated under Swedish conditions with respect to traffic, climate and materials using accelerated pavement testing and long-term pavement performance studies. The mechanistic-empirical pavement design guide (M E PDG), the incremental-recursive mechanistic-empirical CalME model (CalME), and the PErmanent Deformation of asphalt concrete layer for ROads (PEDRO) model generally showed both useful features and limitations. LÄS MER

  3. 2. Monitoring of product variants in biopharmaceutical downstream processing : Mechanistic and data-driven modeling approaches

    Författare :Patricia Roch; Carl-Fredrik Mandenius; Gunnar Hörnsten; Franciscus van der Berg; Linköpings universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : During the manufacturing of biopharmaceuticals, a multistep purification strategy is employed to remove process-related impurities and product variants, to achieve high product quality, assuring patients’ safety. To guarantee that biopharmaceuticals are safe and to accomplish quality, strict policies were established by regulatory agencies as well as guiding principles, such as Quality by Design and process analytical technology. LÄS MER

  4. 3. Predictive Modeling of Lake Eutrophication

    Författare :Jan Mikael Malmaeus; Lars Håkanson; Kurt Pettersson; Jürg Bloesch; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Earth sciences; mass balance model; dynamic model; mechanistic model; phosphorus; LEEDS; suspended particulate matter; settling velocity; sedimentation; accumulation sediments; burial; diffusion; climate scenario; Erken; Balaton; Kinneret; Batorino; Miastro; Naroch; Galten; Ekoln; Geovetenskap; Earth sciences; Geovetenskap;

    Sammanfattning : This thesis presents predictive models for important variables concerning eutrophication effects in lakes. The keystone is a dynamic phosphorus model based on ordinary differential equations. LÄS MER

  5. 4. Modeling and Optimization of Reversed-Phase Chromatography : Effects of Modulators and Temperature

    Författare :Karolina Arkell; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Reversed-phase chromatography; Hydrophobic interaction chromatography; Mechanistic modeling; INSULIN; KCl; Ethanol; Temperature; Multi-objective optimization; Constraint; Solubility;

    Sammanfattning : Many widespread diseases, such as diabetes, various types of cancer, and aggressive versions of influenza, are treated or prevented with biopharmaceuticals. Biopharmaceuticals are drugs that are based on proteins, peptides, antibodies, attenuated viruses (vaccines), and other biomolecules that are synthesized predominately in bacteria, yeast, and mammalian cells. LÄS MER

  7. 5. Modeling and Mechanistic Investigation of α-synuclein aggregation

    Författare :Alexander Svanbergsson; Neural plasticitet och reparation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Our understanding of the α-synuclein aggregation process and the consequences thereof is currently limited, which in turn prevents the development of targeted therapeutic interventions. The work presented here, as a part of this thesis, is focused on expanding our understanding of the molecular events involved in α-synuclein aggregation. LÄS MER