Sökning: "Mechanistic Model"

Visar resultat 1 - 5 av 337 avhandlingar innehållade orden Mechanistic Model.

  1. 1. Predictive Modeling of Lake Eutrophication

    Författare :Jan Mikael Malmaeus; Lars Håkanson; Kurt Pettersson; Jürg Bloesch; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Earth sciences; mass balance model; dynamic model; mechanistic model; phosphorus; LEEDS; suspended particulate matter; settling velocity; sedimentation; accumulation sediments; burial; diffusion; climate scenario; Erken; Balaton; Kinneret; Batorino; Miastro; Naroch; Galten; Ekoln; Geovetenskap; Earth sciences; Geovetenskap;

    Sammanfattning : This thesis presents predictive models for important variables concerning eutrophication effects in lakes. The keystone is a dynamic phosphorus model based on ordinary differential equations. LÄS MER

  3. 2. Cannabinoids as neuroprotective agents : a mechanistic study

    Författare :Olov Nilsson; Christopher Fowler; Edward Högestätt; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cannabinoid; neuroprotection; inflammation; cytokine; neutrophil; Pharmacology; Farmakologi;

    Sammanfattning : Glucose and oxygen supply to the brain is critical for its proper function and when it is restricted as during a stroke, neurons and glial cells quickly become necrotic leading to structural damage as well as functional impairment and even death. To date there are few effective therapies that inhibit the neurodegenerative process and improves the outcome for the affected individual. LÄS MER

  4. 3. Covariate Model Building in Nonlinear Mixed Effects Models

    Författare :Jakob Ribbing; E. Niclas Johnsson; Mats O. Karlsson; Janet Wade; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

    Sammanfattning : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. LÄS MER

  5. 4. Dispersal of bryophytes across landscapes

    Författare :Niklas Lönnell; Kristoffer Hylander; Bengt Gunnar Jonsson; Sebastian Sundberg; Johan Ehrlén; Risto Virtanen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; anemochory; bryophytes; colonization; connectivity; diaspores; dispersal kernel; establishment; spore dispersal; long-distance dispersal; mechanistic model; mosses; realized dispersal; spore release; Lagrangian stochastic model; wind dispersal; Plant Ecology; växtekologi;

    Sammanfattning : Dispersal, especially long-distance dispersal, is an important component in many disciplines within biology. Many species are passively dispersed by wind, not least spore-dispersed organisms.In this thesis I investigated the dispersal capacity of bryophytes by studying the colonization patterns from local scales (100 m) to landscape scales (20 km). LÄS MER

  7. 5. Water and Heat Transport in Road Structures : Development of Mechanistic Models

    Författare :Klas Hansson; Lars-Christer Lundin; Kurt Roth; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hydrology; Water flow; Heat flow; Unsaturated flow; Freeze-thaw; Numerical models; Uncertainty analysis; Sensitivity analysis; Roads; Overland flow; Flow patterns; TDR; Water content reflectometer; Calibration; Fractures; Hydrologi; Hydrology; Hydrologi;

    Sammanfattning : The coupled transport of water and heat, involving freezing and thawing, in the road structure and its immediate environment is important to consider for optimal design and maintenance of roads and when assessing solute transport, of e.g. de-icing salt, from roads. LÄS MER