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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Radioimmunotherapy in Experimental Head and Neck Squamous Cell Carcinoma : Tumour-targeting in vitro and in vivo

    Författare :Junping Cheng; Matti Anniko; Mats Engström; Vladimir Tolmachev; Torgny Stigbrand; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Otorhinolaryngology; squamous cell carcinoma; radioimmunotherapy; cell line; tumour targeting; radionuclide; nude mice; Otorhinolaryngologi; Otorhinolaryngology; Otorhinolaryngologi;

    Sammanfattning : Radioimmunotherapy (RIT) has been shown to be a practicable way to treat head and neck squamous cell carcinoma. A specific antibody recognizes the charasteristic structure of tumour cells when loaded with cytotoxic agents (toxins, drugs, radionuclides, etc). LÄS MER

  3. 2. Diagnosis and Radioimmunotherapy of Head and Neck Squamous Cell Carcinomas

    Författare :Tomas Ekberg; Matti Anniko; Jörgen Carlsson; Eva Munck-Wikland; Uppsala universitet; []
    Nyckelord :Otorhinolaryngology; head and neck squamous cell carcinoma; tumor targeting; radionuclide targeting; PET; therapy; diagnistics; antibodies; Otorhinolaryngologi;

    Sammanfattning : The diagnosis and treatment of patients with advanced tumors in the head and neck is an interesting challenge where there is a need for new approaches in diagnostics and adjuvant treatment. Differences in antigen expression between tumors and normal tissues provide a means for application of antibody-based targeting techniques. LÄS MER

  4. 3. Targeting molecules for diagnostics of Head and Neck squamous cell carcinoma

    Författare :Anna-Karin Haylock; Marika Nestor; Göran Laurell; Matti Anniko; Katrine Riklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HNSCC; CD44v6; radio-immunodiagnosis; immuno-PET; tumor targeting; antibodies; antibody fragments; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

    Sammanfattning : To personalize treatment for cancer, correct staging of the primary tumor, nodal disease and metastatic disease is of essence. By targeting tumor specific receptors with radiolabeled antibodies, specificity and accuracy of imaging may be improved. LÄS MER

  5. 4. Sensorimotor Brain Plasticity in Stroke Patients with Dysphagia : A Methodological Study on Investigation and Treatment

    Författare :Mary Hägg; Matti Anniko; Ulla Friberg; Hélène Pessah-Rasmussen; Uppsala universitet; []
    Nyckelord :Otorhinolaryngology; Brain plasticity; Controls; Dysphagia; Deglutition; Facial palsy; Lip force; Muscle training; Orofacial regulation; Reliability; Sensitivity; Specificity; Stroke; Swallowing capacity; Otorhinolaryngologi;

    Sammanfattning : AimsThe aims of the thesis were to validate investigation instruments for stroke patients with dysphagia, and to improve oropharyngeal dysphagia therapies.Methods/ResultsA Lip Force Meter, LF 100, affirmed excellent intra- and inter-reliability, sensitivity and specificity. LÄS MER

  7. 5. Time-related Aspects of Otoprotection : Experimental Studies in Rat

    Författare :Adnan Lidian; Matti Anniko; Petri Olivius; Uppsala universitet; []
    Nyckelord :sensorineural hearing loss; Edaravone; brain-derived neurotrophic factor; auditory brainstem response; Sprague-Dawley rat; distortion product otoacoustic emission; Pseudomonas aeruginosa exotoxin A.; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

    Sammanfattning : Intratympanic injection of various otoprotectants through the round window membrane (RWM) might become available in the near future as an alternative to the currently available medical and surgical methods used to treat several inner ear diseases. The most common outcome of such diseases is sensorineural hearing loss (SNHL). LÄS MER