Sökning: "Mats Hidestrand"

Hittade 1 avhandling innehållade orden Mats Hidestrand.

1. 1. Structure and function of hepatic cytochromes P450 : implications for drug development

   Författare :Mats Hidestrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Prediction of human drug metabolism in vivo by use of in vitro systems is of immense importance in drug development since it allows avoidance of drugs coming out on the market that are subjected to interindividual variability in metabolism or causes drug-drug interactions, both of which in turn can lead to adverse drug reactions and result in non-optimal treatment. In the present investigations the importance of P450 haplotype on substrate specificity was studied as well as a comparison of different in vitro systems for optimal prediction of in vivo drug metabolism. LÄS MER