Sökning: "Mats Gustafsson"

Visar resultat 16 - 20 av 43 avhandlingar innehållade orden Mats Gustafsson.

  1. 16. Towards High-Throughput Phenotypic and Systemic Profiling of in vitro Growing Cell Populations using Label-Free Microscopy and Spectroscopy : Applications in Cancer Pharmacology

    Författare :Obaid Aftab; Mats Gustafsson; Neil Carragher; Uppsala universitet; []
    Nyckelord :label free vesicle detector; high-throughput; phase contrast microscopy; Library of Pharmacologically Active Compounds; High Content Screening; fluorometric microculture cytotoxicity assay; nuclear magnetic resonance; mass spectrometry;

    Sammanfattning : Modern techniques like automated microscopy and spectroscopy now make it possible to study quantitatively, across multiple phenotypic and molecular parameters, how cell populations are affected by different treatments and/or environmental disturbances. As the technology development at the instrument level often is ahead of the data analytical tools and the scientific questions, there is a large and growing need for computational algorithms enabling desired data analysis. LÄS MER

  3. 17. Fusing Domain Knowledge with Data : Applications in Bioinformatics

    Författare :Claes Andersson; Jan Komorowski; Mats Gustafsson; Yves Moreau; Uppsala universitet; []
    Nyckelord :Bioinformatics; cell cycle; cancer chemotherapy; predictive tests; performance estimation; bioinformatics; Bioinformatik;

    Sammanfattning : Massively parallel measurement techniques can be used for generating hypotheses about the molecular underpinnings of a biological systems. This thesis investigates how domain knowledge can be fused to data from different sources in order to generate more sophisticated hypotheses and improved analyses. LÄS MER

  4. 18. Characterization of Biomolecular Interactions Using a Multivariate Approach

    Författare :Karl Andersson; Mats Gustafsson; Jörgen Carlsson; Olav Kvalheim; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Chemometrics; QSAR; Interaction; kinetics; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : This thesis presents a novel bioinformatic methodology denoted the bio-chemometric approach. The methodology is designed for generation of detailed descriptions and predictions of biomolecular interactions. It is based on multivariate analysis of the sensitivity of a biomolecular interaction to multiple minor changes in the experimental conditions. LÄS MER

  5. 19. Optimal Detectors for Transient Signal Families and Nonlinear Sensors : Derivations and Applications

    Författare :Daniel Asraf; Mats Gustafsson; Anders Grennberg; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Signalbehandling; optimal detection; transient signals; noncoherent detection; unknown arrival time; ultrasonic nondestructive testing; nonlinear sensor; stochastic resonance; Signalbehandling; Signal processing; Signalbehandling; Signal Processing; signalbehandling;

    Sammanfattning : This thesis is concerned with detection of transient signal families and detectors in nonlinear static sensor systems. The detection problems are treated within the framework of likelihood ratio based binary hypothesis testing. LÄS MER

  7. 20. Machine Learning Based Analysis of DNA Methylation Patterns in Pediatric Acute Leukemia

    Författare :Christofer Bäcklin; Mats Gustafsson; Markus Ringnér; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Recent evidence indicate that DNA methylation (DNAm) play a central role in the development and progression of the disease. LÄS MER