Sökning: "Matrix metalloproteinase"

Visar resultat 11 - 15 av 90 avhandlingar innehållade orden Matrix metalloproteinase.

  1. 11. Role of platelets and neutrophils in regulating trypsinogen activation and tissue damage in acute pancreatitis

    Författare :Aree Abdulla; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protease activation; adhesion molecule; chemokine; intravital flourecence microscopy; matrix metalloproteinase.;

    Sammanfattning : Acute pancreatitis is an inflammatory disease characterized by a diverse spectrum of clinical presentations ranging from a mild and self-limiting to a severe and systemic disorder. The relationship between inflammation and proteolytic activation in pancreatitis is an elusive issue. LÄS MER

  3. 12. Basement membrane collagens in pancreatic cancer : novel stroma-derived tumor markers and regulators of cancer cell growth

    Författare :Daniel Öhlund; Malin Sund; Peter Naredi; Matthias Löhr; Umeå universitet; []
    Nyckelord :Pancreatic cancer; tumor marker; basement membrane; type IV collagen; type XVIII collagen; matrix metalloproteinase; integrin; autocrine loop; tumor stroma; kirurgi; Surgery;

    Sammanfattning : Background: Among the common malignancies, pancreatic cancer has the shortest long-term survival. The aggressive, rapid, and infiltrative growth pattern of pancreatic cancer, together with the lack of specific symptoms, often leads to late diagnosis. LÄS MER

  4. 13. Studies of Mesenchymal Progenitor Cells and Tumour Growth, Integrins and Matrix Metalloproteinases

    Författare :Lars Bryngelsson Ohlsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Tumour inhibition; cancer; onkologi; cancerology; Cytologi; oncology; Cytology; Biologi; Biology; Medicin människa och djur ; Medicine human and vertebrates ; Integrin matrix metalloproteinase interaction; Immunologi; serologi; transplantation; Proteins; enzymology; Proteiner; enzymologi; serology; Mesenchumal progenitor cells;

    Sammanfattning : In this thesis we characterize the effect of mesenchymal progenitor cells (MPCs) on tumour growth, and show that MPCs can have inhibitory effects on tumour development. We developed a method to subcutaneously transplant tumour cells, cultured in vitro in a pre-formed gelatin matrix, that made it possible to study the early phases of tumour development. LÄS MER

  5. 14. Leukocyte-derived matrix metalloproteinase-9 in patients with coronary artery disease : Associations with psychological stress and glucocorticoid sensitivity

    Författare :Simon Jönsson; Lena Jonasson; Anna Lundberg; Magnus Bäck; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Inflammation is closely associated with development of atherosclerosis. The proteolytic enzyme matrix metalloproteinase (MMP)-9 is considered to play a prominent role in this process. MMP-9 has also been introduced as a marker for plaque vulnerability. LÄS MER

  7. 15. Extracellular matrix remodelling proteases in acute appendicitis and their impact on appendiceal perforation

    Författare :Anna Solberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; appendicitis; perforation; extracellular matrix; MMP-9; TIMP-1; uPA; PAI-1;

    Sammanfattning : Abstract Background Appendicitis is associated with varying degradation of extracellular matrix involved in tissue injury. The principal aim of this study was to investigate whether immunoreactive techniques could illustrate the course and severity of appendicitis and separate the different inflammatory grades, phlegmonous, gangrenous and perforated appendicitis, from each other and from uninflamed appendix. LÄS MER