Sökning: "Matilda Lampinen Salomonsson"

Hittade 1 avhandling innehållade orden Matilda Lampinen Salomonsson.

1. 1. Chemical Derivatization in Combination with Liquid Chromatography Tandem Mass Spectrometry for Detection and Structural Investigation of Glucuronides

   Författare :Matilda Lampinen Salomonsson; Mikael Hedeland; Ulf Bondesson; Calle Nilsson; Uppsala universitet; []
   Nyckelord :Pharmaceutical chemistry; Derivatization; mass spectrometry; glucuronide; drug metabolism; increased sensitivity; structural investigation; 2-chloro-1-methylpyridinium iodide CMPI ; 1-ethyl-3- 3-dimethylaminopropyl -carbodiimide EDC ; 2-picolylamine PA ; 1; 2-dimethylimidazole-4-sulfonyl chloride DMISC ; Farmaceutisk kemi;

   Sammanfattning : This thesis presents novel approaches for structural investigation of glucuronides using chemical derivatization in combination with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn).Today, LC-ESI-MSn is the dominant technique for quantitative as well as qualitative analyses of metabolites, due to its high sensitivity and selectivity. LÄS MER