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1. 1. Pathways that govern hematopoietic stem cell fate

   Författare :Matilda Billing; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :hematopoies; Hematopoietic stem cell; TGF beta; Smad signaling; GATA2; p57;

   Sammanfattning : Hematopoietic stem cells (HSCs) compose a rare population of undifferentiated cells, residing in the bone marrow of adult individuals, ensuring life-long maintenance and replenishment of the blood system. This fantastic achievement is possible owing to two special characteristics of the HSCs: their ability to make copies of themselves (self-renew), and their capacity to differentiate to all lineages of the blood system. LÄS MER