Sökning: "Mast cell secretion"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Mast cell secretion.

  1. 1. The Role of Fc gamma Receptors and Mast Cell Chymase in Autoimmune Arthritis

    Författare :Sofia Magnusson; Sandra Kleinau; Jeanette Leusen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fc gamma receptors; rheumatoid arthritis; antibodies; mast cells; mast cell; Immunology; Immunologi; Immunologi; Immunology;

    Sammanfattning : In autoimmune diseases such as rheumatoid arthritis (RA), self-reactive antibodies are present at high levels, which contributes to disease pathogenesis. The antibodies mediate their effect predominantly by binding to Fc gamma receptors (FcγR) on various leukocytes, such as monocytes, macrophages and mast cells, where FcγR ligation leads to cell activation. LÄS MER

  3. 2. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion

    Författare :Ying Gao; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; extracellular fluids; Hematologi; Medicin människa och djur ; Haematology; Medicine human and vertebrates ; neutrophil; granule; secretory lysosome; sorting; phagocytosis; degranulation.; mast cell; hematopoietic cell; inflammation; soluble TNF receptor;

    Sammanfattning : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. LÄS MER

  4. 3. A role of CD44 in atherosclerosis? Studies in mice and humans

    Författare :Sara Sjöberg; Göteborgs universitet; []
    Nyckelord :CD44; atherosclerosis; interleukin-6; T cell; mast cell;

    Sammanfattning : Atherosclerosis is an inflammatory disease that can lead to clinical complications such as myocardial infarction and stroke. Expressed in both vascular and inflammatory cells, adhesion molecule CD44 can be cleaved from the cell surface, and soluble CD44 can be detected in blood. LÄS MER

  5. 4. Mast cells in chronic inflammatory diseases : new insights in mast cell function and phenotype

    Författare :Ricardo Filipe Da Silva Carvalho; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mast cells are multifunctional cells that play important roles in health and disease. They are long lived cells with the capacity to be activated several times. Upon activation mast cells release a huge array of mediators. The nature of the mediators released is dependent on the stimuli. LÄS MER

  7. 5. Function and Regulation of B-cell Subsets in Experimental Autoimmune Arthritis

    Författare :Anna-Karin E. Palm; Sandra Kleinau; Susanna Cardell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; B cells; marginal zone; autoimmune arthritis; spleen; lymph node; antigen presentation; Fc gamma receptor IIb; complement receptors 1 and 2; mast cells; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Immunology;

    Sammanfattning : B lymphocytes play a significant role in autoimmune arthritis, with their function stretching beyond autoantibody production to cytokine secretion and presentation of autoantigen. However, the involvement and activation of different B-cell subset in the autoimmune response is not fully clear. LÄS MER