Sökning: "Massively parallel sequencing"

Visar resultat 11 - 15 av 36 avhandlingar innehållade orden Massively parallel sequencing.

  1. 11. Analysis of RNA and DNA sequencing data : Improved bioinformatics applications

    Författare :Benjamín Sigurgeirsson; Joakim Lundeberg; Simon Anders; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA sequencing; exome sequencing; bioinformatics; gene expression; differential expression; variant calling; Bioteknologi; Biotechnology;

    Sammanfattning : Massively parallel sequencing has rapidly revolutionized DNA and RNA research. Sample preparations are steadfastly advancing, sequencing costs have plummeted and throughput is ever growing. This progress has resulted in exponential growth in data generation with a corresponding demand for bioinformatic solutions. LÄS MER

  3. 12. Characterization of structural chromosomal variants by massively parallel sequencing

    Författare :Jesper Eisfeldt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chromosomal Structural Variation (SV) such as translocations, inversions, deletions, and duplications are rearrangements of one or several DNA molecules. SVs are widespread across the human genome, and each individual carries thousands of SVs of different types and sizes. LÄS MER

  4. 13. Technologies for Single Cell Genome Analysis

    Författare :Erik Borgström; Afshin Ahmadian; Sten Linnarsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA; sequencing; single molecule; single cell; whole genome amplification; exome sequencing; emulsions; barcoding; phasin; Biotechnology; Bioteknologi;

    Sammanfattning : During the last decade high throughput DNA sequencing of single cells has evolved from an idea to one of the most high profile fields of research. Much of this development has been possible due to the dramatic reduction in costs for massively parallel sequencing. LÄS MER

  5. 14. Transcriptomic and taxonomic profiling of periodontitis by massively parallel sequencing

    Författare :Anna Lundmark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Periodontitis is a microbial-induced, chronic inflammatory disease that affects tissue and bone anchoring the teeth, and can ultimately lead to tooth loss. In addition, periodontitis may contribute to systemic diseases, such as cardiovascular disease (CVD), diabetes, rheumatoid arthritis (RA), and inflammatory bowel diseases. LÄS MER

  7. 15. Analysis of genetic variations in cancer

    Författare :Johanna Hasmats; Joakim Lundeberg; Carsten Daub; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Mutations; Variations; Single Nucleotide Polymorphism; DNA; RNA; Genome; Massively Parallel Sequencing; Exome Sequencing; Toxicity;

    Sammanfattning : The aim of this thesis is to apply recently developed technologies for genomic variation analyses, and to ensure quality of the generated information for use in preclinical cancer research.Faster access to a patients’ full genomic sequence for a lower cost makes it possible for end users such as clinicians and physicians to gain a more complete understanding of the disease status of a patient and adjust treatment accordingly. LÄS MER