Sökning: "Martin Ott"

Visar resultat 6 - 10 av 17 avhandlingar innehållade orden Martin Ott.

  1. 6. Organization of mitochondrial gene expression in yeast : Specific features of organellar protein synthesis

    Författare :Kirsten Kehrein; Martin Ott; Thomas A Fox; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; translation; bc1 complex; ribosome; gene expression; Biochemistry; biokemi;

    Sammanfattning : Mitochondria contain their own genetic system, encoding key subunits of the oxidative phosphorylation system. These subunits are expressed by an organelle-specific gene expression machinery. LÄS MER

  3. 7. Ribosomal translocation in real time : Method development to Applications

    Författare :Chang-il Kim; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ribosome; EF-G; pyrene mRNA; aminoglycoside; ribosomal protein; GTP hydrolysis; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : Translational elongation is the process in which the ribosome adds one amino acid at a time to the nascent peptide chain. As the ribosome elongates the peptide chain by 14 - 20 amino acids per second and performs hundreds of such cycles per protein, ‘elongation’ is one of the most crucial steps in translation. LÄS MER

  4. 8. Structure and Biogenesis of Membrane Proteins

    Författare :Mama Ndi; Martin Ott; Alexander Kastaniotis; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cbp3; cytochrome b; respiratory complex III; alternative translation initiation and sodium proton exchange; Biochemistry; biokemi;

    Sammanfattning : Membrane proteins make up about one-third of the cellular proteome. The diverse roles that membrane proteins have in cells include major life-sustaining processes, making them major drug targets. LÄS MER

  5. 9. Evolutionary Mechanisms Shaping Bacterial Translation Termination

    Författare :Shreya Pundir; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein; Release Factor; Translation; Termination; Stop codon; Evolution; Mutation; Kinetics; Cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Translation termination in bacteria involves precise reading of stop codons (UAA, UAG, UGA) and coordinated peptidyl-tRNA hydrolysis by the class-I release factors (RFs) on the ribosome (70S). This thesis investigates the evolutionary and post-translational modification mechanisms of these RFs and the concurrent effect on bacterial translation termination. LÄS MER

  7. 10. Structural characterisation of mitochondrial macromolecular complexes using cryo-EM : Mitoribosome biogenesis and respiratory chain supercomplex

    Författare :Sorbhi Rathore; Martin Ott; Daniel Wilson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitoribosome biogenesis; mitoribosome assembly factors; yeast respiratory supercomplexes; single particle electron cryo-microscopy; cryo-EM sample preparation; Biochemistry; biokemi;

    Sammanfattning : Mitochondria, popularly known as powerhouse of the cell, contain specialised mitoribosomes that synthesise essential membrane proteins. These essential proteins are required to form enzyme complexes, which carry out the process of oxidative phosphorylation (OXPHOS). LÄS MER