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Visar resultat 1 - 5 av 26 avhandlingar som matchar ovanstående sökkriterier.

1. 1. QM/MM free-energy perturbation and other methods to estimate ligand-binding affinities

   Författare :Martin Olsson; Beräkningskemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Computer-aided drug design; protein–ligand binding; molecular dynamics; free-energy perturbation; QM MM; convergence;

   Sammanfattning : Experimental drug discovery is very time-consuming, risky and comes at a huge cost, typically several billion USD per drug. Even though decades of experimental drug discovery have provided cures of many diseases, there are still diseases for which there is no effective drug available. LÄS MER

3. 2. Problematic substance use and co-occurring psychiatric problems in young Clinical patients and in criminal justice clients. Studies of mortalilty, measurements and intervention

   Författare :Martin Olsson; Lund Psykiatri; []
   Nyckelord :Substance use; psychiatric co-morbidity; Addiction Severity Index; criminal justice population; adolescent; young adult; Interactive Voice Response; hair analysis; Non-Medical Prescription Opioid Use;

   Sammanfattning : .... LÄS MER

4. 3. Diesel Engnine Cam and Roller Follower Tribology

   Författare :Martin Olsson; Maskinelement; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; vibration and acoustic engineering; vacuum technology; hydraulics; Cam; Roller follower; Mechanical engineering; Damage progress; Running in; Maskinteknik; hydraulik; vakuumteknik; vibrationer; akustik;

   Sammanfattning : Surfaces subjected to rolling and sliding contacts may suffer from contact fatigue. The cam and roller follower mechanism is a typical rolling and sliding contact. LÄS MER

5. 4. Particle-Induced Phase Separation in Aqueous Solutions containing Colloidal Particles and Adsorbing Polymers

   Författare :Martin Olsson; Fysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polymer technology; biopolymers; Polymerteknik; theoretical calculations; particle-induced phase separation; phase behaviour; surfactant; colloidal particles; adsorbing polymer;

   Sammanfattning : The influence of added colloidal particles on the phase behaviour of a polymer solution was investigated. Binary, quasi-binary and mixed polymer solutions were used in the study, where at least one of the polymers had an affinity for the surfaces of the colloidal particles. LÄS MER

7. 5. Phenotypic Specification of Striatal Progenitors; Evidence for both cell-autonomous and environmental control as studied by transplantation into the adult and developing rodent brain

   Författare :Martin Olsson; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; striatal projection neurons; striatal development; somatostatin; parvalbumin; neuronal differentiation; neural transplantation; medial ganglionic eminence; lateral ganglionic eminence; forebrain dvelopment; cholinergic; embryonic; thyroid transcription fa; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : The striatum is the major component of the ventral telencephalon and basal ganglia, involved in the processing of cortical information. The vast majority of the neuronal population in the striatum are striatal projection neurons, with connection to the globus pallidus and substantia nigra. LÄS MER