Sökning: "Martin Malmsten"

Visar resultat 11 - 15 av 15 avhandlingar innehållade orden Martin Malmsten.

1. 11. Antimicrobial Peptide Interactions with Phospholipid Membranes : Effects of Peptide and Lipid Composition on Membrane Adsorption and Disruption

   Författare :Adam A Strömstedt; Martin Malmsten; Georges Belfort; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial; peptide; adsorption; liposome; membrane; melittin; cholesterol; tryptophan; phospholipid; bilayer; PHARMACY; FARMACI; Pharmaceutical Physical Chemistry; farmaceutisk fysikalisk kemi;

   Sammanfattning : The interactions between antimicrobial peptides and phospholipid membranes were investigated, in terms of lipid headgroup variations and the role of cholesterol, as well as peptide composition and structure. Also strategies for increasing proteolytic stability were evaluated. LÄS MER

3. 12. Controlled release gel formulations and preclinical screening of drug candidates

   Författare :Tofeeq Ur-Rehman; Gerhard Gröbner; Mikael Elofsson; Åsa Gylfe; Martin Malmsten; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; poloxamer; drug delivery; micellization; DMSO; calorimetry; NMR. in situ gelation; chitosan; preclinical pharmacokinetics; type III secretion inhibitors; Physical chemistry; Fysikalisk kemi; Pharmaceutics; galenisk farmaci;

   Sammanfattning : Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermo-reversible poloxamer gels, which are suitable for novel drug delivery applications. LÄS MER

4. 13. Physico-Chemical Investigations of, and Characterization of Model Membranes for, Lipid-Peptide Interactions

   Författare :Per Wessman; Katarina Edwards; Martin Malmsten; Michel Lafleur; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

   Sammanfattning : The main focus of this thesis is on the effects caused by α-helical peptides on liposome structure, the impact of cholesterol on the peptide-membrane interactions, and the effect of aggregate curvature on the peptide affinity. Results of the studies show that the membrane destabilizing effect of the cationic α-helical peptide melittin is modulated by cholesterol. LÄS MER

5. 14. Microgel Interactions with Peptides and Proteins : Consequence of Peptide and Microgel Properties

   Författare :Ronja Widenbring; Martin Malmsten; Per Hansson; Catherine Picart; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Binding; Degradation; Enzyme; Gel; Hydrogel; Microgel; Peptide; Protein; Release; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

   Sammanfattning : Microgels are lightly cross-linked hydrogel particles in the sub-micrometer to micrometer size range with a capacity to drastically change their volume in response to changes in the external environment. Microgels have an ability to bind and store substances such as biomacromolecular drugs, notably proteins and peptides, and release them upon stimuli, making them potential candidates as drug delivery vehicles and functional biomaterials. LÄS MER

7. 15. Reflective assent in basic care : A study in nursing ethics

   Författare :Kersti Malmsten; Göran Lantz; Steven Edwards; Uppsala universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; Religion; Nursing Ethics; Communicative Ethics; Feminist Ethics; Virtue Ethics; BasicCare; Consent; Reflective Assent; Bodily Knowledge; Power; Vulnerability; Embodiment; Sensuality; Reciprocity; Interdependent Autonomy; Consolation; Human Dignity; Empowerment; Religionsvetenskap Teologi; Religion Theology; Religionsvetenskap Teologi; etik; Ethics; Ethics;

   Sammanfattning : This study discusses nursing ethics in relation to basic care. The practice of basic care andrelated knowledge are often understood as tacit knowledge, a kind of familiarity-knowledgethat often has been neglected by philosophical scrutiny. LÄS MER