Sökning: "Marion Kusche-Gullberg"

Hittade 5 avhandlingar innehållade orden Marion Kusche-Gullberg.

  1. 1. EXT Proteins in Heparan Sulfate Biosynthesis

    Författare :Marta Busse; Marion Kusche-Gullberg; Tarja Kinnunen; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Heparan sulfate (HS) is a long unbranched polysaccharide composed of alternating glucosamine and hexuronic (glucuronic or iduronic) acid residues. Modification by sulfate groups in various positions generates a highly heterogeneous molecule. LÄS MER

  2. 2. Regulation of Heparan Sulfate 6-O-Sulfation Patterns

    Författare :Anh-Tri Do; Marion Kusche-Gullberg; Ulf Lindahl; Malcolm Lyon; Uppsala universitet; []
    Nyckelord :Biochemistry; Heparan Sulfate; Biosynthesis; 6-O-sulfation; 6-O-sulfotransferases; 6-O-endosulfatases; Nematostella; Biokemi;

    Sammanfattning : Heparan sulfates (HSs) are linear, negatively charged polysaccharides composed of alternating hexuronic acid (glucuronic acid or iduronic acid) and glucosamine residues that can be substituted to varying degrees with sulfate groups. HS, localized in the extracellular matrix and on the surface of most cells, interacts with a large number of proteins. LÄS MER

  3. 3. Glycosaminoglycan Biosynthesis and Function in Zebrafish Development : Sugars Shaping Skeletons

    Författare :Judith Habicher; Johan Ledin; Per Erik Ahlberg; Marion Kusche-Gullberg; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : Heparan sulfate (HS) and chondroitin/dermatan sulfate (CS/DS) proteoglycans are glycosylated proteins with important roles in animal development and homeostasis. HS and CS/DS are long, linear glycosaminoglycan (GAG) polysaccharides and attached to a core protein they form proteoglycans. LÄS MER

  4. 4. Studies on the Role of UDP-Glucose Dehydrogenase in Polysaccharide Biosynthesis

    Författare :Elisabet Roman; Marion Kusche-Gullberg; Hakon Leffler; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; UDP-glucose dehydrogenase; polysaccharide biosynthesis; glycosaminoglycan; A. thaliana; E. coli K5; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : Polysaccharides are found in all forms of life and serve diverse purposes. They are enzymatically synthesised from activated monosaccharide precursors, nucleotide sugars. One such nucleotide sugar is UDP-glucuronic acid, which is formed from UDP-glucose by the UDP-glucose dehydrogenase (UGDH) enzyme. LÄS MER

  5. 5. In Vitro Studies of the Substrate Specificities of Heparan Sulfate 2-O- and 6-O-sulfotransferases

    Författare :Emanuel Smeds; Marion Kusche-Gullberg; Ulf Lindahl; Catherine L. R. Merry; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; heparin; sulfotransferase; 2-O-sulfotransferase; 6-O-sulfotransferase; polysaccharide biosynthesis; glycosaminoglycan; O-sulfotransferase; proteoglycan; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Heparan sulfate (HS), a linear negatively charged polysaccharide located at the cell surface and in the extracellular matrix, interacts with, and thereby regulates the functions of numerous proteins. HS-protein interactions depend on the fine structure of HS, especially its sulfation pattern. LÄS MER