Sökning: "Marie Westerlund"
Hittade 1 avhandling innehållade orden Marie Westerlund.
1. On the roles of genes in Parkinson's disease
Sammanfattning : Parkinson’s disease is a progressive neurodegenerative disorder which affects 1% of the population over the age of 60. In order to identify candidate genes with a potential role in Parkinson’s disease pathology, we investigated genes which are involved in protein aggregation and the ubiquitin‐proteasome system (α‐synuclein and ubiquitin carboxy‐terminal hydrolase L1, UCH‐L1), oxidative stress (DJ‐1), mitochondrial function (mitochondrial transcription factor A, TFAM), regulation of drug/toxin levels (multi‐drug resistance 1, MDR1 and alcohol and aldehyde dehydrogenases, ADH and ALDHs), as well as a gene with unknown function, but highly implicated in Parkinson’s disease genetics (leucine‐rich repeat kinase 2, LRRK2). LÄS MER
