Sökning: "Maria Hägg"

Hittade 3 avhandlingar innehållade orden Maria Hägg.

  1. 1. Hypoxia-inducible factors (HIFs) and biological responses, in hypoxia, inflammation and embryonic vascular development

    Författare :Maria Hägg; Göteborgs universitet; []
    Nyckelord :Embryonic stem cell; embryoid body; HIF-1a; hypoxia; VEGF; angiogenesis; vasculogenesis; peritoneal dialysis;

    Sammanfattning : ABSTRACT Low oxygen tension (hypoxia) is a major inducer of neovascularisation and evidence emerging has indicated that oxygen tension and hypoxia-inducible factors (HIFs), a family of oxygen-regulated heterodimeric transcription factors, may play important roles in vascular and hematopoietic development. This thesis has focused on studying molecular and cellular mechanisms, by which cells and organisms sense changes in oxygen tension, and how this signal is transduced by HIFs into downstream signalling. LÄS MER

  3. 2. Translational studies of drug-induced tumor cell death

    Författare :Maria Hägg Olofsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It is essential to understand the mechanisms of action of anticancer drugs in order to obtain good treatment results. I have in the present thesis studied clinically used anticancer agents as well as other agents that induce tumor cell death. LÄS MER

  4. 3. Medication-related problems and psychotropic drug use in vulnerable older populations : a focus on acute hospital admissions and cognitive impairment

    Författare :Jonas Kindstedt; Maria Gustafsson; Hugo Lövheim; Eva-Lotta Glader; Staffan Hägg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; older people; cognitive impairment; medication-related problems; psychotropic drugs; Clinical Pharmacology; klinisk farmakologi;

    Sammanfattning : The ageing process involves several physiological changes that affect both pharmacodynamics and pharmacokinetics and that, in combination with a heavier disease burden and more extensive use of medicines, put older people at higher risk of medication-related problems and associated clinical outcomes. The older population is often treated as a homogenous group, when in fact there are factors that render certain individuals more vulnerable to adverse drug effects and other types of medication-related problems. LÄS MER